Approximately 10% to 15% of couples encounter infertility problems in Taiwan. Infertile couples need to search for a lot of information before making a decision regarding their medical treatment plans; therefore, the internet has become one of the best tools for obtaining such information and accessing psychosocial support resources, such as healthcare databases, expert forums or blogs, and support communities. Internet-based interventions may provide infertile couples with healthcare information and psychosocial support to fulfill their individualized care needs, enhance their self-efficacy and problem-solving abilities, and cope effectively with their physical and psychological stress due to infertility. As internet access, computers, and smart phones/mobile devices become more popular, informational technologies applied to healthcare delivery have become a trend. Currently, our understanding of applying information from the internet to healthcare delivery remains limited. Healthcare providers may endeavor to provide infertile couples with innovative, accessible, and effective ways to obtain healthcare resources through informational technologies. This article briefly introduces the definition of infertility, explains its causes and treatments, describes the psychosocial stresses that infertile couples may face, and explores how to utilize internet resources to improve the quality of care for infertile couples. Hopefully, this article may serve as a reference for healthcare providers for developing internet-based care interventions for infertile couples.