The growing elderly population has increased the importance of fulfilling caregiving roles among in adult children. As a group, caregivers of the elderly relatives face a high risk of general dysphoria and clinically significant anxiety and depression. Despite the large and growing body of data on caregiver burden or stress, significantly gaps exist in our understanding of the factors that contribute to individual differences in the negative caregiving experiences. Recent research suggests that the relationship variables significantly influence individual ability to tolerate the strain of caregiving, and the results of this study have been interpreted within the framework of attachment theory. Therefore, this article focuses on intergenerational caregiving from both theoretical and empirical applications of attachment concept. Notably, this article can provide health professionals and researchers a fuller understanding of the intergenerational caregiving.