After the first case of AIDS was found in the United States, the number of global infections has rapidly increased. Due to the AIDS stigma associated with its name, patients suffered from social isolation and employment difficulties, causing problems of making a living. Moreover, because of the pressure of public opinion caused by AIDS stigma, patients expressed numerous psychological problems, including depression, anxiety, loneliness, low self-esteem, suicide ideation, and poor medical compliance. At the same time, the stigma of AIDS is also the most critical obstacle in the global AIDS epidemiological prevention and control. Only by improving the stigma of AIDS can patients be free from discrimination. Then, they can be ensured their rights on employment, education, privacy, confidentiality, access to information, medical care and support. Hence, whether they are government agencies, medical institutions or the general public, everyone should bravely face the difficulties and problems of AIDS. With prevention, education, counseling, medical testing, treatment, legal and political efforts, AIDS will be no longer discriminated.