過重者代謝症候群與胰島素阻抗之相關性探討

The Association between Metabolic Syndrome and Insulin Resistance in Overweight Cases

詹欣隆(Hsin-Lung Chan) ； 黃麗卿(Lee-Ching Hwang)

《台灣家庭醫學雜誌》 16卷3期 (2006/09) Pp. 181-191

https://doi.org/10.7023/TJFM.200609.0181

摘要

Three hundred and thirty-one volunteers, who were overweight and had high body mass index (BMI≧24 kg/m^2), participated in this study. They were required to fill up their medical history, life style, and family history. Their body weight, height, waist, hip circumference, and blood pressure (BP) were then measured. The blood was sampled to determine the fasting plasma glucose (FPG), insulin level, total cholesterol, triglyceride (TG), and high-density lipoprotein cholesterol (HDL-C). Quantification of insulin resistance (IR) was evaluated by the formula of Homeostatic Model Assessment Index-Insulin Resistance (HOMA-IR). The metabolic syndrome (MS) was defined by the American Heart Association/National Heart, Lung, and Blood Institute (AHA/NHLBI) and was modified by Asian-Pacific standard. The obtained results showed that the MS presented by the level of BP, total cholesterol, plasma insulin, TG, and HDL-C was higher in men than women. Average IR and log IR levels were significantly higher in men than women (p＜0.05). IR values obtained from both men and women were all correlated with the MS. However, this correlation displayed gender difference that all of these five items of the MS for women were correlated with the IR and only two items (TG and FPG) of the MS for men were associated with the IR. Data from regression analyses showed that women had four of these five MS items excluding high BP while men had only one item (high FPG) to be positively related to the IR. Based on these results observed, we conclude that there is a positive correlation and gender difference between the IR and MS.

並列摘要

Three hundred and thirty-one volunteers, who were overweight and had high body mass index (BMI≧24 kg/m^2), participated in this study. They were required to fill up their medical history, life style, and family history. Their body weight, height, waist, hip circumference, and blood pressure (BP) were then measured. The blood was sampled to determine the fasting plasma glucose (FPG), insulin level, total cholesterol, triglyceride (TG), and high-density lipoprotein cholesterol (HDL-C). Quantification of insulin resistance (IR) was evaluated by the formula of Homeostatic Model Assessment Index-Insulin Resistance (HOMA-IR). The metabolic syndrome (MS) was defined by the American Heart Association/National Heart, Lung, and Blood Institute (AHA/NHLBI) and was modified by Asian-Pacific standard. The obtained results showed that the MS presented by the level of BP, total cholesterol, plasma insulin, TG, and HDL-C was higher in men than women. Average IR and log IR levels were significantly higher in men than women (p＜0.05). IR values obtained from both men and women were all correlated with the MS. However, this correlation displayed gender difference that all of these five items of the MS for women were correlated with the IR and only two items (TG and FPG) of the MS for men were associated with the IR. Data from regression analyses showed that women had four of these five MS items excluding high BP while men had only one item (high FPG) to be positively related to the IR. Based on these results observed, we conclude that there is a positive correlation and gender difference between the IR and MS.

並列關鍵字

metabolic syndrome ； insulin resistance ； HOMA-IR ； overweight

參考文獻

Tan CE,Ma S,Wai D,Chew SK,Tai ES(2004).Can we apply the National Cholesterol Education Program Adult Treatment Panel definition of the metabolic syndrome to Asians?.Diabetes Care.27,1182-1186.

Park HS,Oh SW,Cho SI,Choi WH,Kim YS(2004).The metabolic syndrome and associated lifestyle factors among South Korean adults.Int J Epidemiol.33,328-336.

Bonora E,Kiechl S,Willeit J(2003).epidemiology and more extensive phenotypic description. Cross-sectional data from the Bruneck Study.Int J Obes Relat Metab Disord.27,1283-1289.

Ford ES,Abbasi F,Reaven GM(2005).Prevalence of insulin resistance and the metabolic syndrome with alternative definitions of impaired fasting glucose.Atherosclerosis.181,143-148.

Chuang SY,Chen CH,Chou P(2004).Prevalence of metabolic syndrome in a large health check-up population in Taiwan.J Chin Med Assoc.67,611-620.