Coronavirus disease 2019 (COVID-19) has become a global pandemic. High volumes of COVID-19 patients have not only tested the capacity of the medical system, but have placed a heavy burden on medical and nursing professionals as well. Most patients with asymptomatic or mild COVID-19 could be cared for at home as part of home isolation or quarantine rather than being sent to the hospital for treatment. The authors carried out a literature search focusing on COVID-19 disease characteristics, needs assessment for home-based care, environment preparation for home-based caregivers and patients, and guidance for patients' self-care. By highlighting the relative information, the authors hope that patients with asymptomatic or mild COVID-19 could be properly and safely cared for at home during home isolation or quarantine, which, in turn, could help alleviate the stress on medical care systems.