In this research, we explored how occupational therapists used a therapeutic piano activity to cure a patient with a head injury and cervical-HIVD (Herniated Intervertebral Disc)with major depression. The approach was based on theories of neurodevelopmental treatment and the Model of Human Occupation. We used an in-depth interview methodology of qualitative research to sum up the helpfulness of a piano activity for patients at work, at leisure, and in activities of daily living, 3 aspects of occupational areas. We discuss our findings of using a piano activity to treat patients with head injuries, which may offer references for clinical use for related staff in the area of rehabilitative care.