This study aimed to analyze and identify key issues being studied in leading Management Information Systems (MIS) journals collected in an ISI database. With the help of co-citation analysis and factor analysis, thirteen core issues were identified, including: (1) Technology Acceptance; (2) Information Technology (IT), Organization Performance, and Competitive Advantage; (3) IT and Organizational Structure; (4) Case Study and Methodology Issues; (5) Trust Issues in IT; (6) Knowledge Management; (7) Measurement Issues in MIS study; (8) Diffusion of Innovation; (9) Success Factors of IT; (10) Research Modeling and Approach; (11) Theory, Research and Practice; (12) MIS as an academic discipline; and (13) Enterprise Information Systems. These results can help MIS researchers and practitioners gain a better awareness of core and significant issues being studied in the field.