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微胞液相層析的滯留機制及在藥物分析上之應用

Retention Mechanisms of Micellar Liquid Chromatography in Pharmaceutical Analysis Applications

摘要


微胞液相層析法(MLC)是液相層析法(HPLC)的另一種應用方法,可有效的分析不同性質的分析物,並且能應用在醫藥製劑及生物樣品中藥物之直接分析。本論文回顧以MLC法分析不同性質的藥物(離子的、中性的、極性範圍廣的),及不同分析條件(用離子型和非離子界面活性劑,加入鹽和有機溶劑,不同pH值)對分析物滯留行為的影響,提供一簡要的檢討報告。

並列摘要


Micellar liquid chromatography (MLC) is a branch of high-performance liquid chromatography (HPLC), and it can be used for the simultaneous determination of most drug materials in pharmaceutical preparations, or in biological samples. In this review, the retention behaviour of solutes of different drugs (ionic or neutral exhibiting a wide range of polarities), and the conditions (with ionic and non-ionic surfactants, add salt and organic solvent, and varying pH) are discussed.

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