利用超音波震盪造霧後製備幾丁聚醣微粒

Preparation of Chitosan Microparticles by Ultrasonic Atomizer

陳泓廷(Hong-Ting Chen)

指導教授 ： 鄭國忠

國立臺北科技大學/工程學院/生物科技研究所/碩士(2009年)

摘要

本實驗為利用沉水型超音波造霧器架設噴霧乾燥裝置以製備幾丁聚醣微粒。所製備之幾丁聚醣微粒的大小、形狀與表面型態會受到此噴霧乾燥裝置的操作條件所影響，例如空氣流量、幾丁聚醣溶液濃度與和其交聯劑（戊二醛）的濃度。以0.01到2wt%的幾丁聚醣濃度所收集到之微粒，藉由掃描式電子顯微鏡的觀察，結果發現不同濃度的幾丁聚醣溶液會影響所收集的微粒粒徑分佈，濃度越高平均粒徑越大，濃度在0.01到2wt%所製備出之微粒粒徑90%的分佈範圍介於0.5到3μm之間，各濃度的數目平均粒徑也皆介於0.6到2μm。添加交聯劑（戊二醛）後其粒徑也無有明顯的變化趨勢，在幾丁聚醣0.5wt%分別添加戊二醛0.25wt%、0.5wt%後所製備的微粒數目平均粒徑分別為1.22μm、1.57μm。

關鍵字

幾丁聚醣微粒 ； 噴霧乾燥 ； 超音波

並列摘要

Chitosan solutions were ultrasonic atomized; then dried by a heated column. The size and morphology of the dried chitosan particles were observed by a scanning electron microscope (SEM). Chitosan particles with narrow distributed diameter from about 0.2 through 3um can be prepared by the ultrasonic atomization under different composition of solution. It was found that the particle size increases with increasing of the concentration of chitosan in acetic solution. Furthermore, chitosan particles loaded with theophylline were prepared by a co-spray drying with the crosslinking agent.

並列關鍵字

Chitosan ； Spray-drying ； Ultrasonic

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