以二氧化錳搭配次氯酸鈉及界陎活性劑去除水中異布洛芬之研究

目前台灣普遍使用之非類固醇消炎止痛藥 (NSAIDs)當中，異布洛芬(Ibuprofen)使用量已達千噸，其造成環境汙染問題已不容忽視。而錳氧化物為土壤中常見成份，也是自然界中具有粒徑小表面積大特性之氧化劑，當錳氧化物表面電位轉換，有利於去除各種汙染物。由於錳氧化物只能氧化含有苯胺、酚及磷酸類官能機之有機化合物，但異布洛芬不含有上列官能基，可能不易去除，因此本研究主要是以次氯酸鈉及界面活性劑，增加錳氧化物的去除能力。研究結果發現，次氯酸鈉與界面活性劑能分別增加異布洛芬去除率，當次氯酸鈉加入水樣後會使異布洛芬被氧化，而界面活性劑只會對異布洛芬進行吸附反應。合併次氯酸鈉與界面活性劑實驗結果得知，二氧化錳對異布洛芬整體去除率分別在酸性、中性與鹼性環境中可達99%、 60% 和46%。為探討異布洛芬被二氧化錳氧化情形，本研究使用高效液相層析儀(HPLC)合併DAD與Applied Biosystems API 4000Q MS/MS進行光譜測定與未知產物分析，發現異布洛芬中COOH官能基會被氯取代，但許多其他未知產物仍然未被偵測到，因此探討整體反應中未知產物是否為影響環境與人體之有毒性物質，仍需更詳細地進行分析研究。

關鍵字

異布洛芬；錳氧化物；次氯酸鈉；界面活性劑；氧化；吸附；高效液相層析儀；液相層析串連質譜儀

並列摘要

Among the widespread use of non-steroidal anti-inflammatory drugs (NSAIDs) in Taiwan, the usage of ibuprofen has been over one thousand tons per year and its environmental impact can not be ignored. Manganese dioxide is a common material in the soil and is high reactive because of its high oxidation potential nature and large surface area. Various organic pollutants containing aniline, phenol or phosphate group can be removed by it. However, ibuprofen dose not has above functional groups, so it can not be oxidized by manganese dioxide alone. This research used hypochlorite acid and surfactants to enhance the reactivity of manganese dioxide. Both hypochlorite acid and surfactant can increase the removal of ibuprofen. The addition of hypochlorite acid can lead to the oxidation of ibuprofen while the addition of surfactant can only increase the adsorption capacity of manganese dioxide. Combination of the addition of hypochlorite acid and surfactant can significantly increase the removal of ibuprofen. The removal of ibuprofen reached to 99%, 60% and 46% in acidic, neutral and alkaline condition, respectively. In order to find the oxidation products of ibuprofen, we use HPLC with DAD and LC/MS/MS to detect the ultraviolet and MS spectrum of the products. We found the carboxylic group in the ibuprofen was replaced by the chloride. However, lots of other products can not be determined, so the toxicity for human and environmental impacts of this method still need further researches to be investigated.

並列關鍵字

Ibuprofen ； manganese dioxide ； hypochlorite acid ； surfactant ； oxidation ； adsorption ； HPLC/DAD ； LC/MS/MS

參考文獻

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以二氧化錳搭配次氯酸鈉及界陎活性劑去除水中異布洛芬之研究

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