- 期刊
新生兒及兒童的霧氣藥物傳送影響因素之探討
Influence of Aerosolized Drug Delivery on Neonatal and Pediatric
摘要
新生兒及兒童患有肺部疾病時霧氣藥物在治療上扮演著重要的角色。然而，因新生兒及兒童的生理結構與成人差異大，不同年齡認知程度、呼吸型態與配合度及不同設備等種種因素，導致藥物的沉降量也隨著改變，而使治療效果差異大，因此，給與病童霧氣治療時須進行系統性評估，視各種情境選擇適當設備。當使用面罩介面傳送霧氣，應盡量將面罩緊密地放在病童臉上，或是經由氧氣罩給藥，但避免”Blow-by”技術。藥物劑量的考量層面，在無副作用產生情況下，目前傾向於使用與成人相同的劑量。在插管病童執行霧氣治療時，許多可能改變藥物沈降的因素應均列入考量，以達到最佳的治療效果。
並列摘要
Aerosolized drug delivery plays an important role in treating neonate/pediatric patients with pulmonary diseases. However, children are not miniature adults, and it is a challenge to delivery aerosolized drug to neonate/pediatric. In comparison to adults, the drug deposition in the neonatal/pediatric is influenced greatly by anatomy structure, cognition, cooperation, respiratory patterns in different age, and type of devices. As the result, the therapeutic effects of the aerosolized drug might be altered. Different aerosol delivery devices and interfaces should be chosen carefully according to patients' age and disease condition. When an aerosol mask is used to delivery drug, it should be tightly fitted on child's face; or an oxygen hood can be replaced. The most important, ”blow-by” technique should be avoided. Current evidence tents to suggestion that, as long as no adverse effect occurs, medication dosage should be same as adult one. Factors which might affect aerosolized drug deposition should be considered while aerosolized drugs are administered through an artificial airway and mechanical ventilation.