A case of 59 y/o male with alcohol and betel quid chewing habits, he came to our out patient department due to unhealed ulcer over right side buccal mucosa for about 6 months. Biopsy was done and histopathologic report was ”squamous cell carcinoma”. After specify surveys were done, he was diagnosed as T2N0M0, cancer stage Ⅱ. Wide excision was performed under general anesthesia and the defect was repaired with artificial dermis. Surgical histopathologic report was ”well-differentiated squamous cell carcinoma” and the specimen margin was free of malignant cell. Patient did not feel any significant discomfort during admission. The wound healing was uneventful and he was discharged as schedule. Patient received regular follow up after discharged. No evidence of intraoral recurrence and neck metastasia on post-operation 4(superscript th) visit. Compared to autogenous skin graft, artificial dermis is also a good choice for early stage oral cancer post-excision defect repaire.