In 1985, Harold M. Frost discovered that the bone injury would increase the remodeling of soft and hard tissue around the wound region, and the special phenomenon was called as "regional acceleratory phenomenon (RAP)". Today, in addition to being used widely in orthopedic surgery, RAP has also been introduced to dentistry. The most famous application is the use of periodontal surgery to accelerate tooth movement and shorten the treatment time of orthodontic therapy. This article will introduce the development and clinical applications of RAP in dentistry, and conduct a systematic review.