With the rapid development of cross-border e-commerce, its personnel training has become a major focus of professional teaching and reform in colleges and universities. It is of great practical value to study the practice teaching issues on cross-border e-commerce for application-oriented undergraduate colleges and universities. Starting with the curriculum design of cross-border e-commerce specialty group in schools, this paper studies five factors influencing students' satisfaction with cross-border e-commerce practical teaching curriculum, analyses the shortcomings of current practical teaching curriculum design, and puts forward the optimization countermeasures for improving students' satisfaction with practical teaching curriculum design.