- 學位論文
光動態影像定量量測系統的設計
A Measurement System for Quantifying the Dynamic Propagation of Light
摘要
隨著光學元件與技術的快速發展，光學式的量測方法已有許多醫療診斷方面的應用，為了使生醫光學的應用技術更加成熟，我們必須更了解光在生物組織中的光學特性。而同調光在生物組織內的散射性干涉是許多生醫光學量測的基礎，也是造成量測上的限制所在，因此本研究的目的在發展觀察同調光在散射性生物組織中動態擴散的測量系統，希望能對光與生物組織的特性能有更深入的了解，以進而研發更多的應用。 本研究依照白光干涉原理，設計一套量測系統讓光入射至樣本，光經過多重散射後從樣本側面散射出來，再與另一束參考光相互干涉，在兩束光行走相同距離的位置，可產生最明顯的光干涉斑點。將拍攝到的影像再以電腦程式運算處理得出光斑點對比影像，即為生物組織內特定時間區段的光動態擴散影像。 本研究設計製作適當尺寸的光學機構，以固定小型化的量測系統，讓每次量測的條件能保持一致，方便對動態擴散影像做定量量測。將量測結果與數學模型的模擬結果相互比對，有助於反推出更精準的光學參數，進而找出光在生物組織內的分佈範圍以及光的擴散路徑。
並列摘要
There are many medical measurement and diagnosis methods benefit from the great progress in optical components and techniques. In order to promote more applications in biomedical optics, we have to have better understanding of the optical characteristics of biological tissues. The interference of scattered coherence light in biological tissue is a basic phenomenon found in many biomedical optics measurements. However, it generally causes a limitation in the range of measurement. The purpose of this study is to study the dynamic propagation of light in biological tissue. The results would be helpful to know how the scattering propagation of light in turbid media. The measurement system is based on a wide spectrum interferometer. The sample beam is injected into a scattering sample, and it encounters multiple scattering before it leaves the sample from the viewing surface. Then, the scattering light interferes with the reference beam. For light in two beams travel the same distance, the interference forms a clear speckle image. Using a computer to acquire the speckle image and calculate its speckle contrast, the image of light that propagates a specific distance in a scattering media is obtained. A minimized measurement system was built in this study. The condition of experiment can be kept the same for different measurements. This allows us to carry out quantitative evaluation. The measurement image also can be compared with the simulation results to find out the more appropriate values of tissue optical properties. This will be helpful to estimate the distribution and propagation of light in the biological tissue.
參考文獻
延伸閱讀
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