Urolithiasis is a common problem encountered in primary care practice. Around 80% of patients with urolithiasis form calcium stones, most of which are constituted primarily by calcium oxalate. Typical symptoms and signs include hematuria, renal colic, and may be accompanied by nausea and vomiting. Differential diagnosis includes upper urinary tract infection, some diseases of the gastrointestinal and hepatobiliary system, and problems from the female reproductive system. The diagnosis of urolithiasis is confirmed with imaging studies, and kidney, ureter, bladder radiography, computed tomography of the abdomen and pelvis, and ultrasound of kidneys and bladder are frequently used. As to the management of urolithiasis, patients should receive adequate pain control, antispasmodic agents, such as calcium channel blockers, α-adrenergic blockers, and be instructed to strain their urine in the acute phase. Also, the need for urology consultation or referral for further appropriate management should be evaluated.