The large-scale circuit simulation for MOSFET circuits with interconnects has been investigated in this paper. Our strategy is to use the reinforced Selective-tracing Waveform Relaxation (STWR) algorithm that equipped with a transmission line calculator. Strengthening methods for STWR and accelerating methods for the embedded transmission line calculation has been proposed, including the time step control scheme and parallel computing. All proposed methods have been implemented and tested to justify their superior performance.