Suppression of Age-Dependent Increase in Insulinemia in Early Middle-Aged Females with Exercise Habit


Tung-Hsiung Hsu;Yuh-Feng Liu;Shin-Da Lee;Shu-Man Chen;Jo-Ping Lee;Chin-Lung Fang;Te-Chih Liu;Chia-Hua Kuo

Key Words

exercise ; aging ; cholesterol ; triglyceride ; insulin ; glucose tolerance


The Chinese Journal of Physiology

Volume or Term/Year and Month of Publication

51卷5期(2008 / 10 / 01)

Page #

263 - 268

Content Language


English Abstract

Circulating insulin concentration has been suggested as a biomarker for human longevity. The goal of the study was to determine the insulin levels under a glucose-challenged condition for the sedentary and physical active females in early middle age. We measured serum insulin levels for following groups: young sedentary (Y-SED, age 19.7±0.2 years), middle-aged sedentary (M-SED, age 42.3±3.1 years), young physically active (Y-EX, age 20.7±0.5 years), and middle-aged physically active (M-EX, age 40.3±2.8 years). Oral glucose tolerance test (OGTT) and insulin measurement were performed under overnight fasted condition. Triglyceride, cholesterol, body mass index (BMI), and waist-to-hip ratio (WHR) were also determined in all subjects. While fasted glucose and insulin levels were not different among 4 groups, glucose and insulin levels under OGTT were greater in the M-SED group than those in the Y-SED group. The M-EX subjects exhibited lower insulin levels on OGTT, as compared to the M-SED group, and were similar to the level of Y-SED. BMI and WHR of the M-SED group were comparable to those of the M-EX group. Triglyceride and cholesterol levels were highly associated with age and WHR but not the level of physical activity. The current study found a substantially greater insulin response on OGTT in the healthy sedentary females aged ~40, as compared to those in the young sedentary and the middle-aged physically active females, independent of weight status. The result of the study also suggests that accumulating 150 min of weekly exercise is sufficient to counteract the adverse effect of age on insulin sensitivity.

Topic Category 醫藥衛生 > 基礎醫學
  1. Wang, P.T.,Chiang, I.T.,Lin, C.Y.,Hou, C.W.,Chen, C.Y.,Lee, H.H.,Chang, W.H.,Kuo, C.H.(2006).Effect of a two-month detraining on glucose tolerance and insulin sensitivity in athletes-link to adrenal steroid hormones.Chinese J. Physiol.,49,251-257.
  2. Barzilai, N.,Banerjee, S.,Hawkins, M.,Chen, W.,Rossetti, L.(1998).Caloric restriction reverses hepatic insulin resistance in aging rats by decreasing visceral fat.J. Clin. Invest.,101,1353-1361.
  3. Basu, R.,Breda, E.,Oberg, A.L.,Powell, C.C.,Dalla Man, C.,Basu, A.,Vittone, J.L.,Klee, G.G.,Arora, P.,Jensen, M.D.,Toffolo, G.,Cobelli, C.,Rizza, A.(2003).Mechanisms of age-associated deterioration in glucose tolerance: contribution of alterations in insulin secretion, action, and clearance.Diabetes,52,1738-1748.
  4. Bryner, R.W.,Toffle, R.C.,Ullrich, I.H.,Yeater, R.A.(1997).The effects of exercise intensity on body composition, weight loss, and dietary composition in women.J. Am. Coll. Nutr.,16,68-73.
  5. Cefalu, W.T.,Wang, Z.Q.,Werbel, S.,Bell-Farrow, A.,Crouse, J.R.,Hinson, W.H.,Terry, J.G.,Anderson, R.(1995).Contribution of visceral fat mass to the insulin resistance of aging.Metabolism,44,954-959.
  6. Chen, M.,Bergman, R.N.,Pacini, G.,Porte, D.(1985).Pathogenesis of age-related glucose intolerance in man: Insulin resistance and decreased beta cell function.J. Clin. Endocrinol. Metab.,60,13-20.
  7. Colman, E.,Toth, M.J.,Katzel, L.I.,Fonong, T.,Gardner, A.W.,Poehlman, E.T.(1995).Body fatness and waist circumference are independent predictors of the age-associated increase in fasting insulin levels in healthy men and women.Int. J. Obes. Relat. Metab. Disord.,19,798-803.
  8. DeFronzo, R.A.,Jacot, E.,Jequier, E.,Maeder, E.,Wahren, J.,Felber, J.P.(1981).The effect of insulin on the disposal of intravenous glucose. Results from indirect calorimetry and hepatic and femoral venous catheterization.Diabetes,30,1000-1007.
  9. Facchini, F.S.,Hua, N.,Abbasi, F.,Reaven, G.M.(2001).Insulin resistance as a predictor of age-related diseases.J. Clin. Endocrinol. Metab.,86,3574-3578.
  10. Gandapur, A.S.,Manan, M.,Nazir, G.,Uzma, N.,Chawla, J.A.,Jadoon, A.,Tauqeer, A.(2006).Comparison of lipid profile and apoprotein in sedentary workers and those involved in regular exercise.J. Ayub. Med. Coll. Abbottabad.,18,16-20.
  11. Gumbiner, B.,Polonsky, K.S.,Beltz, W.F.,Wallave, P.,Bretchel, G.,Fink, R.(1989).Effects of aging on insulin secretion.Diabetes,38,1549-1556.
  12. Harris, M.I.,Flegal, F.M.,Cowie, C.C.,Eberhardt, M.S.,Golstein, D.E.,Little, R.R.,Weidmeyer, H.S.,Bryd-Holt, D.D.(1998).Prevalence of diabetes, impaired fasting glucose and impaired glucose tolerance in U.S. adults: the Third Nation Health and Nutrition Examination Survey, 1988-1994.Diabetes Care,21,518-524.
  13. Heliovaara, M.,Aromaa, A.(1981).Parity and obesity.J. Epidemiol. Community Health,35,197-199.
  14. Huang, Y.J.,Chen, M.T.,Fang, C.L.,Lee, W.C.,Yang, S.C.,Kuo, C.H.(2006).A possible link between exercise-training adaptation and dehydroepiandrosterone sulfate-an oldest-old female study.Int. J. Med. Sci.,3,141-147.
  15. Ivy, J.L.,Zderic, T.W.,Fogt, D.L.(1999).Prevention and treatment of non-insulin-dependent diabetes mellitus.Exerc. Sport Sci. Rev.,27,1-35.
  16. Kahn, S.E.,Larson, V.G.,Beard, J.C.,Cain, K.C.,Fellingham, G.W.,Schwartz, R.S.,Veith, R.C.,Stratton, J.R.,Cerqueira, M.D.,Abrass, I.B.(1990).Effect of exercise on insulin action, glucose tolerance, and insulin secretion in aging.Am. J. Physiol.,258,937-943.
  17. Kern, M.,Wells, J.A.,Stephens, J.M.,Elton, C.W.,Friedman, J.E.,Tapscott, E.B.,Pekala, P.H.,Dohm, G.L.(1990).Insulin responsiveness in skeletal muscle is determined by glucose transporter (Glut-4) protein level.Biochem. J.,270,397-400.
  18. Kopelman, P.G.(2000).Obesity as a medical problem.Nature,404,635-643.
  19. Lee, W.C.,Chen, S.M.,Wu, M.C.,Hou, C.W.,Lai, Y.C.,Laio, Y.H.,Lin, C.H.,Kuo, C.H.(2006).The role of dehydroepiandrosterone levels on physiologic acclimatization to chronic mountaineering activity.High Alt. Med. Biol.,7,228-236.
  20. Racette, S.B.,Evans, E.M.,Weiss, E.P.,Hagberg, J.M.,Holloszy, J.O.(2006).Abdominal adiposity is a stronger predictor of insulin resistance than fitness among 50-95 year olds.Diabetes Care,29,673-678.
  21. Reaven, G.M.(1991).Insulin resistance and compensatory hyperinsulinemia: role in hypertension, dyslipidemia, and coronary heart disease.Am. Heart J.,121,1283-1288.
  22. Roth, G.S.,Lane, M.A.,Ingram, D.K.,Mattison, J.A.,Elahi, D.,Tobin, J.D.,Muller, D.,Metter, E.J.(2002).Biomarkers of caloric restriction may predict longevity in humans.Science,297,811.
  23. Scheen, A.J.(2005).Diabetes mellitus in the elderly: insulin resistance and/or impaired insulin secretion?.Diabetes Metab.,31,5S27-5S34.
  24. Tonino, R.P.(1989).Effect of physical training on the insulin resistance of aging.Am. J. Physiol.,256,352-356.
Times Cited
  1. Sergej M. Ostojic,Morteza Jourkesh,Julio Calleja(2010).Effects of Short-Term Dehydroepiandrosterone Supplementation on Body Composition in Young Athletes.Chinese Journal of Physiology,53(1),19-25.