Title

Comparison of Protective Effects between Oat β-Glucan and Phenol-Rich Extracts in Hyperlipidemic ICR Mice

Translated Titles

燕麥β-葡聚糖與多酚萃取物降血脂功能之比較研究

Authors

李鶯(Ying Li);羅陽超(Yang-Chao Luo);陳鋼(Gang Chen);肖甄磊(Zhen-Lei Xiao);王芹(Qin Wang);趙磊(Lei Zhao);籍保平(Bao-Ping Ji)

Key Words

燕麥 ; β-葡聚糖 ; 多酚酸 ; 高脂血症 ; HMG-CoA還原酶 ; Oat ; β-glucan ; Phenolic acids ; Hyperlipidemia ; HMG-CoA reductase

PublicationName

藥物食品分析

Volume or Term/Year and Month of Publication

19卷1期(2011 / 03 / 01)

Page #

49 - 57

Content Language

英文

Chinese Abstract

燕麥中的β-葡聚糖(GE)已被廣泛認爲是降低膽固醇的主要成分,然而燕麥中的多酚萃取物(PE)也被認爲具抗高血脂潛能。本研究以餵食高脂飼料之ICR小鼠爲實驗動物,比較和評估燕麥多酚萃取物和β-葡聚糖的降血脂功能。實驗共進行12週,結果多酚萃取物和β-葡聚糖均具顯著降膽固醇功能,能降低血清總膽固醇、血清低密度脂蛋白膽固醇及肝臟膽固醇。燕麥多酚萃取物能顯著降低肝臟三酸甘油酯,抑制肝臟HMG-CoA還原酶活性,並且改善肝臟抗氧化防禦系統。燕麥β-葡聚糖則能顯著增加小鼠中性膽固醇和膽汁酸的排泄。本研究顯示燕麥β-葡聚糖和多酚萃取物均能預防小鼠高脂血症;膽固醇代謝和抗氧化防禦體系的研究,證明了燕麥中這兩種成分各有不同的降血脂機轉。

English Abstract

β-Glucan in oat is widely considered as the main ingredient for the anti-hypercholesterol effects; however, phenolic compounds in oat are also regarded to possess potential activities against dyslipidemia. In order to understand the underlying mechanisms thoroughly, it is of great significance to evaluate and compare the hypolipidemic properties exerted by oat phenol-rich extract (PE) and β-glucan extract (GE) in hyperlipidemic ICR mice induced by high-fat diet. The study was conducted for 12 weeks. Both PE and GE showed a significant hypocholesterolemic action by reducing the concentration of serum total cholesterol (TC), low density lipoprotein cholesterol and hepatic TC. Only PE reduced the hepatic triacylglycerol (TG), inhibited hepatic 3-hydroxy-3-methylglutary CoA reductase activities and improved the hepatic antioxidant defense system. However, GE significantly increased fecal excretion of neutral cholesterol and bile acids. This study demonstrated that not only β-glucan but also oat phenolic acids contributed to a preventive effect on hyperlipidemia. Based on the cholesterol metabolism and antioxidant defense system, the effects of the two functional components of oat were exerted in different ways.

Topic Category 醫藥衛生 > 藥理醫學