Translated Titles

Sex Differences in Brain Structure between Students Talented in Math and Science and Developed Peers


郭靜姿(Ching-Chih Kuo);林慶波(Ching-Po Lin);張馨仁(Hsin-Jen Chang);周坤賢(Kun-Hsien Chou);曾琦芬(Christine Chi-Fen Tseng);張玉佩(Yu-Pei Chang);林燁虹(Yeh-Hong Lin)

Key Words

灰質容積 ; 性別差異 ; 磁振造影 ; 數理能力優異 ; gray matter volume ; sex difference ; magnetic resonance imaging (MRI) ; talent in math and science



Volume or Term/Year and Month of Publication

57卷2期(2012 / 06 / 01)

Page #

25 - 64

Content Language


Chinese Abstract

本研究參與者包括36位高中數理能力優異學生(16男,20女)及37 位普通學生(20男,17女)。研究工具含:「高中學校能力測驗」、「國中基測成績」與「磁振造影」(MRI)。MRI係以SPM的像素型態分析方法(VBM)進行統計。研究結果顯示:一、數優組與普通組在多個皮質區灰質容積有差異。數優組在IQ及數理能力相關的皮質區灰質容積高於普通組;而普通組在動作及高級感覺皮質區灰質容積高於數理能力優異組。二、性別在多個皮質區灰質容積有差異。男生組在計算能力相關、訊息連結、負面情緒記憶等皮質區灰質容積顯著高於女生組;而女生組在認知、高級感覺等皮質區灰質容積顯著高於男生組。三、綜合能力與性別的比較,研究者推估先天能力與後天學習都與大腦發展有關。

English Abstract

In this study, we compare the sex differences in brain structure between math- and science-talented (MST) students and their typically developed (TD) peers, involving 36 MST (16 male and 20 female) and 37 TD (20 male and 17 female) students. The research instruments used in this study were the ”High School Intelligence Test,” the ”Basic Competence Test for Junior High School Students,” and magnetic resonance imaging (MRI). MRI data were processed with voxel-based morphometery (VBM) implemented in statistical parametric mapping (SPM). The results show that (1) MST students displayed larger gray matter volumes than TD students did in the cortical regions related to intelligence and math/science achievement scores; TD students showed larger gray matter volumes than MST students did in motor and somatosensory cortical regions; (2) Male students showed greater gray matter volumes than female students did in the cortical regions involved in mathematical tasks, information processing, and negative emotions; female students showed larger gray matter volumes than their male counterparts did in higher cognitive and somatosensory cortical regions; (3) The results of this study indicate that both innate and acquired abilities might affect brain development.

Topic Category 社會科學 > 教育學
  1. 簡茂發、何榮桂、郭靜姿(2008)。高級中等學校能力測驗(修訂)。臺北市:中國行為科學社。Chian, M.-F., Ho, R.-G., & Kuo, C.-C. (2008). Senior High School Ability Test (Revised from the Otis-Lennon School Ability Test, OLSAT 8). Taipei, Taiwan: Chinese Behavior Science Society.。
  2. Andreasen, N. C.,O''Leary, D. S.,Ehrhardt, J.(1993).Intelligence and brain structure in normal individuals.American Journal of Psychiatry,150(1),130-134.
  3. Ashburner, J.,Friston, K. J.(2000).Voxel-based morphometry-The methods.NeuroImage,11,805-821.
  4. Baker, D. R.,Jones, D. P.(1993).Creating gender equality: Cross-national gender stratification and mathematical performance.Sociology of Education,66(2),91-103.
  5. Benbow, C. P.(1992).Academic achievement in math and science between ages 13 and 23: Are there differences in the top one percent of ability.Educational Psychology,84(1),51-61.
  6. Benbow, C. P.(1988).Sex differences in mathematical reasoning ability in intellectually talented preadolescents: Their nature, effects, and possible causes.Behavioral and Brain Sciences,11(2),169-183.
  7. Benbow, C. P.,Stanley, J. C.(1980).Sex differences in mathematical ability: Fact or artifact?.Science,210,1262-1264.
  8. Benbow, C. P.,Stanley, J. C.(1983).Sex differences in mathematical reasoning ability: More facts.Science,222,1029-1031.
  9. Blanton, R. E.,Levitt, J. G.,Peterson, J. R.,Fadale, D.,Sporty, M. L.,Lee, M.,Toga, A. W.(2004).Gender differences in the left inferior frontal gyrus in normal children.NeuroImage,22(2),626-636.
  10. Blazquez, P. M.,Hirata, Y.,Highstein, S. M.(2004).The vestibulo-ocular reflex as a model system for motor learning: What is the role of the cerebellum.Cerebellum,3(3),188-192.
  11. Brett, M.,Johnsrude, I. S.,Owen, A. M.(2002).The problem of functional localization in the human brain.Neuroscience,3,243-249.
  12. Carter, R.(1998).Mapping the mind.Berkeley, CA:University of California Press.
  13. Casey, M. B.,Brabeck, M. M.(1989).Exceptions to the male advantage on a spatial task: Family handedness and college major as a factor identifying women who excel.Neuropsychologia,27(5),689-696.
  14. Casey, M. B.,Brabeck, M. M.(1990).Women who excel on a spatial task: Proposed genetic and environmental factors.Brain and Cognition,12(1),73-84.
  15. Catsambis, S.(1994).The path to math: Gender and racial-ethnic differences in mathematics participation from middle school to high school.Sociology of Education,67(3),199-215.
  16. Chen, X.,Sachdev, P. S.,Wen, W.,Anstey, K. J.(2007).Sex differences in regional gray matter in healthy individuals aged 44-48 years: A voxel-based morphometric study.NeuroImage,36,691-699.
  17. Cheng, Y.,Chou, K.-H.,Decety, J.,Chen, I.-Y.,Hung, D.,Tzeng, O. T.-L.,Lin, C.-P.(2009).Sex differences in the neuroanatomy of the human mirror-neuron system: A voxel-based morphometric investigation.Neuroscience,158,713-720.
  18. Cheng, Y.,Lee, P.-L.,Yang, C.-Y.,Lin, C.-P.,Hung, D.,Decety, J.(2008).Gender differences in the mu rhythm of the human mirror-neuron system.PLoS ONE,3(5),e2113.
  19. Cheng, Y.,Tzeng, O. J. L.,Decety, J.,Imada, T.,Hsieh, J.-C.(2006).Gender differences in the human mirror system: A magnetoencephalography study.NeuroReport,17(11),1115-1119.
  20. Cheng, Y.,Yang, C.-Y.,Lin, C.-P.,Lee, P.-L.,Decety, J.(2008).The perception of pain in others suppresses somatosensory oscillations.NeuroImage,40,1833-1840.
  21. Colom, R.,Jung, R. E.,Haier, R. J.(2006).Distributed brain sites for the g-factor of intelligence.NeuroImage,31(3),1359-1365.
  22. Danker, J. F.,Anderson, J. R.(2007).The roles of prefrontal and posterior parietal cortex in algebra problem solving: A case of using cognitive modeling to inform neuroimaging data.NeuroImage,35,1365-1377.
  23. De Frais, C. M.,Nilsson, L.,Herlitz, A.(2006).Sex differences in cognition are stable over a 10-year period in adulthood and old age.Aging, Neuropsychology, and Cognition,13(3-4),574-587.
  24. Dean, D. E.,Rabinowicz, T.,Petetot, J. M. C.,de Courten-Myers, G.(1996).Morphologic gender differences in the human brain: I. Left cerebral neocortex.NeuroImage,3,S573.
  25. Dean, D. E.,Rabinowicz, T.,Petetot, J. M. C.,de Courten-Myers, G.(1996).Morphologic gender differences in the human brain: II. Right cerebral neocortex.NeuroImage,3,S574.
  26. Dehaene, S.,Molko, N.,Cohen, L.,Wilson, A. J.(2004).Arithmetic and the brain.Current Opinion in Neurobiology,14(2),218-224.
  27. Dehaene, S.,Piazza, M.,Pinel, P.,Cohen, L.(2003).Three parietal circuits for number processing.Cognitive Neuropsychology,20(3),487-506.
  28. Diamond, M. C.,Scheibel, A. B.,Murphy, G. M., Jr.,Harvey, T.(1985).On the brain of a scientist: Albert Einstein.Experimental Neurology,88(1),198-204.
  29. Eccles, J.,Wigfield, A.,Harold, R. D.,Blumenfeld, P.(1993).Age and gender differences in children's self- and task perceptions during elementary school.Child Development,64(3),830-847.
  30. Frangou, S.,Chitins, X.,Williams, S. C. R.(2004).Mapping IQ and gray matter density in healthy young people.NeuroImage,23(3),800-805.
  31. Geary, D. C.(1996).Sexual selection and sex differences in mathematical abilities.Behavioral and Brain Science,19(2),229-284.
  32. Glickstein, M.,Waller, Baizer, J.,Brown, J. S.,Timmann, D.(2005).Cerebellum lesions and finger use.Cerebellum,4(3),189-197.
  33. Goldberg, E.(2001).The executive brain: Frontal lobe and the civilized mind.New York, NY:Oxford.
  34. Good, C. D.,Johnsrude, I.,Ashburner, J.,Henson, R. N. A.,Friston, K. J.,Frackowiak, R. S. J.(2001).Cerebral asymmetry and the effects of sex and handedness on brain structure: A voxel-based morphometric analysis of 465 normal adult human brains.NeuroImage,14,685-700.
  35. Grabner, R. H.,Ansari, D.,Reishofer, G.,Stern, E.,Ebner, F.,Neuper, C.(2007).Individual differences in mathematical competence predict parietal brain activation during mental calculation.NeuroImage,38,346-356.
  36. Haier, R. J.,Jung, R. E.,Yeo, R. A.,Head, K.,Alkire, M. T.(2004).Structural brain variation and general intelligence.NeuroImage,23(1),425-433.
  37. Halpern, D. E.(1992).Sex differences in cognitive abilities.Hillsdale, NJ:Lawrence Erlbaum Associates.
  38. Hanakawa, T.,Honda, M.,Okada, T.,Fukuyama, H.,Shibasaki, H.(2003).Neural correlates underlying mental calculation in abacus experts: A functional magnetic resonance imaging study.NeuroImage,19,296-307.
  39. Hanakawa, T.,Honda, M.,Sawamoto, N.,Okada, T.,Yonekura, Y.,Fukuyama, H.,Shibasaki, H.(2002).The role of Rostral Brodmann Area 6 in mental operation tasks: An integrative neuroimaging approach.Cerebral Cortex,12,1157-1170.
  40. Hargreaves, M.,Homer, M.,Swinnerton, B.(2008).A comparison of performance and attitudes in mathematics amongst the 'gifted'. Are boys better at mathematics or do they just think they are.Assessment in Education: Principles, Policy & Practice,15(1),19-38.
  41. Hyde, J. S.,Fennema, E.,Ryan, M.,Frost, L. A.,Hopp, C.(1990).Gender comparisons of mathematics attitudes and affect.Psychology of Women Quarterly,14(3),299-324.
  42. Iacoboni, M.(2001).Playing tennis with the cerebellum.Nature Neuroscience,4(6),555-556.
  43. Im, K.,Lee, J.-M.,Lee, J.,Shin, Y.-W.,Kim, I. Y.,Kwon, J. S.,Kim, S. I.(2006).Gender difference analysis of cortical thickness in healthy young adults with surface-based methods.NeuroImage,31,31-38.
  44. Ioffe, M. E.,Chernikova, L. A.,Ustinova, K. I.(2007).Role of cerebellum in learning postural tasks.Cerebellum,6(1),87-94.
  45. Joshua, B.,Todd, B.(2005).Learned predictions of error likelihood in the anterior cingulate cortex.Science,307(5712),1118-1121.
  46. Justus, T.(2004).The cerebellum and English grammatical morphology: Evidence from production, comprehension, and grammaticality judgments.Cognitive Neuroscience,16(7),1115-1130.
  47. Kaufmann, C.,Puetz, B.,Wilke, M.,Auer, D. P.(2001).Gender differences in GM brain morphology: Voxel based morphometry in 92 healthy young women and men.NeuroImage,13,S989.
  48. Kenney, P. A.,Silver, E. A.(1997).Results from the sixth mathematics assessment of the National Assessment of Educational Progress.Reston, VA:National Council of Teachers of Mathematics.
  49. Kimura, D.(1992).Sex differences in the brain.Scientific American,267,119-125.
  50. Leaton, R.(2003).Fear and the cerebellum.Molecular Psychiatry,8,461-462.
  51. Lewis, R. F.(2003).Context-dependent adaptation of visually-guided arm movements and vestibular eye movements: Role of the cerebellum.Cerebellum,2(2),123-130.
  52. Li, Y.-H.,Liu, Y.,Li, J.,Qin, W.,Li, K.-C.,Yu, C.-S.,Jiang, T.-Z.(2009).Brain anatomical network and intelligence.PloS Computational Biology,5(5),e1000395.
  53. Lindquist, M. M.(1989).Results from the fourth mathematics assessment of the National Assessment of Educational Progress.Reston, VA:National Council of Teachers of Mathematics.
  54. Lloyd, D.(2007)."What do Brodmann Areas do?," Or: Scanning the Neurocracy.Hartford, CT:Program in Neuroscience.
  55. Lubinski, D.,Benbow, C. P.(1992).Gender differences in abilities and preferences among the gifted: Implication for the math-science pipeline.Current Directions in Psychological Science,1(2),61-66.
  56. Lubinski, D.,Benbow, C. P.,Shea, D. L.,Eftekhari-Sanjani, H.,Halvorson, M. B. J.(2001).Men and women at promise for science excellence: Similarity not dissimilarity.Psychological Science,12(4),309-317.
  57. Lubinski, D.,Humphreys, L. G.(1990).A broadly based analysis of mathematical giftedness.Intelligence,14,327-355.
  58. Lüders, E.,Narr, K. L.,Thompson, P. M.,Woods, R. P.,Rex, D. E.,Jancke, L.,Toga, A. W.(2005).Mapping cortical gray matter in the young adult brain: Effects of gender.NeuroImage,26(2),493-501.
  59. Manto, M.,Bastian, A. J.(2007).Cerebellum and the deciphering of motor coding.Cerebellum,6(1),3-6.
  60. Marshall, S. P.,Smith, J. D.(1987).Sex differences in learning mathematics: A longitudinal study with item and error analyses.Educational Psychology,79(4),372-383.
  61. Miall, R. C.,Reckess, G. Z.,Imamizu, H.(2001).The cerebellum coordinates eye and hand tracking movements.Nature Neuroscience,4(6),638-644.
  62. Narr, K. L.,Woods, R. P.,Thompson, P. M.,Szeszko, P.,Robinson, D.,Dimtcheva, T.,Bilder, R. M.(2007).Relationships between IQ and regional cortical gray matter thickness in healthy adults.Cerebral Cortex,17(9),2163-2171.
  63. Nixon, P. D.(2003).The role of cerebellum in preparing response to predictable sensory events.Cerebellum,2(2),114-122.
  64. O''Boyle, M. W.(2005).Some current findings on brain characteristics of the mathematically gifted adolescent.International Education Journal,6(2),247-251.
  65. O''Boyle, M. W.,Hellige, J. B.(1989).Cerebral hemisphere asymmetry and individual differences in cognition.Learning and Individual Differences,1(1),7-35.
  66. O''Boyle, M. W.,Hoff, E. J.(1987).Gender and handedness differences in mirror-tracing random forms.Neuropsychologia,25(6),977-982.
  67. O''Boyle, M. W.,Hoff, E. J.,Gill, H. S.(1995).The influence of mirror reversals on male and female performance in spatial tasks: A componential look.Personality and Individual Differences,18(6),693-699.
  68. Paquier, P. F.,Mariën, P.(2005).A synthesis of the role of the cerebellum in cognition.Aphasiology,19(1),3-19.
  69. Reiss, A. L.,Abrams, M. T.,Singer, H. S.,Ross, J. L.,Denckla, M. B.(1996).Brain development, gender and IQ in children: A volumetric imaging study.Brain,119(5),1763-1744.
  70. Robinson, F. R.,Fuchs, A. F.(2001).The role of the cerebellum in voluntary eye movements.Annual Review of Neuroscience,24,981-1004.
  71. Salman, M. S.(2002).The cerebellum: It's about time! But timing is not everything-New insights into the role of the cerebellum in timing motor and cognitive tasks.Journal of Child Neurology,17(1),1-9.
  72. Sax, L.(2005).Why gender matters: What parents and teachers need to know about the emerging science of sex differences.New York, NY:Broadway Books.
  73. Schlaepfer, T. E.,Harris, G. J.,Tien, A. Y.,Peng, L.,Lee, S.,Pearlson, G. D.(1995).Structural differences in the cerebral cortex of healthy female and male subjects: A magnetic resonance imaging study.Psychiatry Research,61(3),129-135.
  74. Schmithorst, V. J.,Brown, R. D.(2004).Empirical validation of the triple-code model of numerical processing for complex math operations using functional MRI and group independent component analysis of the mental addition and subtraction of fractions.NeuroImage,22(3),1414-1420.
  75. Schutter, D. J. G.,Honk, J. V.(2005).The cerebellum on the rise in human emotion.Cerebellum,4(4),290-294.
  76. Schweighofer, N.,Spoelstra, J.,Arbib, M. A.,Kawato, M.(1998).Role of the cerebellum in reaching movements in humans. II. A neural model of the intermediate cerebellum.European Journal of Neuroscience,10(1),95-105.
  77. Seger, A.,Cincotta, M.(2005).The roles of the Caudate Nucleus in human classification learning.The Journal of Neuroscience,25(11),2941-2951.
  78. Singh, H.,O''Boyle, M. W.(2004).Interhemispheric interaction during visual information processing in mathematically gifted youth, average ability adolescents and college students.Neuropsychology,18(2),371-377.
  79. Springer, S. P.,Deutsch, G.(1998).Left brain, right brain.New York, NY:W. H. Freeman.
  80. Talairach, J.,Tournoux, P.(1988).Co-planar stereotaxic atlas of the human brain.New York, NY:Thieme.
  81. Thomas, H.(1993).A theory explaining sex difference in high mathematical ability has been around for some time.Behavioral and Brain Sciences,16(1),187-215.
  82. Verchinski, B.,Meyer-Lindenberg, A.,Japee, S.,Kohn, P.,Egan, M.,Bigelow, L.,Weinberger, D.(2000).Gender differences in gray matter density: A study of structural MRI images using voxel-based morphometry.NeuroImage,11,S228.
  83. Walsh, M.,Hickey, C.,Duffy, J.(1999).Influence of item content and stereotype situation on gender differences in mathematical problem solving.Sex Roles,41(3-4),219-240.
  84. Wang, W.-L.(2006).Gender differences in gifted children's spatial, verbal, and quantitative reasoning abilities: A preliminary study.Journal of Humanities and Social Science,1,221-236.
  85. Weiner, N. C.,Robinson, S. E.(1986).Cognitive abilities, personality and gender differences in math achievement of gifted adolescents.Gifted Child Quarterly,30(2),83-87.
  86. Wilke, M.,Sohn, J. H.,Byars, A. W.,Holland, S. K.(2003).Bright spots: Correlations of gray matter volume with IQ in a normal pediatric population.NeuroImage,20(1),202-215.
  87. Willson, M. L.,Bower, A. J.,Sherrard, R. M.(2007).Developmental neural plasticity and its cognitive benefits: Olivocerebellar reinnervation compensates for spatial function in the cerebellum.European Journal of Neuroscience,25(5),1475-1483.
  88. Yamasue, H.,Abe, O.,Suga, M.,Yamada, H.,Rogers, M. A.,Aoki, S.,Kasai, K.(2008).Sex-linked neuroanatomical basis of human altruistic cooperativeness.Cerebral Cortex,18(10),2331-2340.
  89. Zhou, X.,Chen, C.,Zang, Y.,Dong, Q.,Chen, C.,Qiao, S.,Gong, Q.(2007).Dissociated brain organization for single-digit addition and multiplication.NeuroImage,35(2),871-880.
  90. Zilles, K.,Kawashima, R.,Dabringhaus, A.,Fukuda, H.,Schormann, T.(2001).Hemispheric shape of European and Japanese brains: 3-D MRI analysis of intersubject variability, ethnical, and gender differences.NeuroImage,13,262-271.
  91. 王文伶(2006)。資優兒童的空間、語文、和數量推理能力之性別差異:一個試驗研究。人文與社會學報,1(9),221-236。