Title

弓形蟲感染之孕婦血清中發炎細胞激素及血纖維蛋白酶原活化因子的變化

Translated Titles

Alteration of inflammatory cytokines and plasminogen activators in serum of pregnant women with Toxoplasma gondii infection

DOI

10.6834/CSMU.2012.00054

Authors

周金山

Key Words

細胞激素 ; 孕婦 ; 組織型血纖維蛋白酶原活化因子 ; 弓形蟲 ; 尿激酶型血纖維蛋白酶原活化因子 ; cytokine ; pregnant women ; tissue-type plasminogen activator ; Toxoplasma gondii ; urokinase-type plasminogen activators

PublicationName

中山醫學大學醫學研究所學位論文

Volume or Term/Year and Month of Publication

2012年

Academic Degree Category

博士

Advisor

賴世展

Content Language

繁體中文

Chinese Abstract

弓形蟲症(toxoplasmosis)是由弓形蟲(Toxoplasma gondii)感染所引起的疾病,此伺機性寄生蟲,在婦女懷孕期間感染時,可經胎盤感染胎兒而引起流產與胎兒先天性疾病。細胞激素(cytokines)與血纖維蛋白酶原活化因子(plasminogen activators, PAs),在許多的感染性疾病均會明顯增加,然而婦女在懷孕期間受弓形蟲感染時,血清中的發炎細胞激素與PAs的表現及所扮演的角色仍不清楚。因此,本研究除了探討在中台灣待產婦(confinement pregnant)受弓形蟲感染的血清流行病學外,更進一步,利用FlowCytomix human Th1/Th2 plex 試驗套組,分析血清中發炎細胞激素的表現量,另外以casein zymography及西方點墨法(western blotting),分別檢測組織型血纖維蛋白酶原活化因子(tissue-type PA, tPA)與尿激酶型血纖維蛋白酶原活化因子(urokinase-type plasminogen activator, uPA)的酵素活性與表現量。結果顯示,在待產婦的血清中有2.7 %(6/220)呈現抗弓形蟲免疫球蛋白 M (immunoglobulin M, IgM)抗體陽性反應,9.1 %(20/220)抗弓形蟲免疫球蛋白 G (immunoglobulin G, IgG)抗體陽性反應,抗弓形蟲IgM陽性及抗弓形蟲IgG陽性之待產婦在總白血球數、嗜酸性白血球數、Th1 發炎細胞激素(如:IFN-γ、 IL-1β、IL-2 與 IL-12 p70)、Th2 發炎細胞激素(IL-10)、tPA與uPA的酵素活性,均較健康待產婦有明顯增加(P<0.05)。因此我們推測當受弓形蟲感染之待產婦 Th1發炎細胞激素、Th 2 發炎細胞激素及tPA、uPA的增加,可能參與弓形蟲症的生理或病理過程。

English Abstract

Toxoplasmosis is an opportunistic protozoal infection caused by the parasite Toxoplasma gondii (T. gondii). During pregnancy, it may cause badly intrauterine damage and sequelae in the newborn by T. gondii infection. Cytokines and plasminogen activators (PAs) are increase in inflammatory diseases, whereas the role of PAs in pregnant women with T. gondii infection is unknown. In this study, we have investigated the seroprevalence to T. gondii in the sera of confinement pregnant women in the central Taiwan. Further, we investigated the levels of cytokine by FlowCytomix multiplex cytokine detection, and measured the activities and levels of tissue-type PA (tPA) and urokinase-type PA (uPA) by casein zymography and Western blotting, respectively, in the sera of onfinement pregnant women serum with T. gondii infection. Six (2.7%) of sera had IgM anti-T. gondii antibodies, and twenty (9.1%) had T. gondii IgG seropositive. Six of IgM seropositive samples were positive for low avidity IgG indicative of acute infection. Total white blood cells and eosinophils were statistically significant increase (P<0.05) in confinement pregnant women with T. gondii infection as compared with normal confinement pregnant women. Th1 cytokines IFN-γ, IL-1β, IL-2 and IL-12 p70, and Th2 cytokines IL-10 in confinement pregnant women of T. gondii IgM/IgG seropositive were significantly increased (P < 0.05) as compared with normal confinement pregnant women. The protein levels and activities of PAs were significant increase in the confinement pregnant women’s serum with T. gondii infection as compared with healthy confinement pregnant women’s and healthy nonpregnant women’s serum. In conclusion, Th1 cytokines, Th2 cytokines, tPA and uPA may be participate in the pathogenesis of toxoplasmosis in pregnant women and may be useful markers of T. gondii infection.

Topic Category 醫藥衛生 > 醫藥總論
醫學院 > 醫學研究所
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