台灣正常組群尿液及唾液內生性珈瑪-羥基丁酸（GHB）參考值之調查研究

洪苡昕

doi:10.6834/CSMU.2013.00103

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台灣正常組群尿液及唾液內生性珈瑪-羥基丁酸（GHB）參考值之調查研究

The Investigation of Urinary and Salivary Endogenous Gamma- Hydroxybutyrate (GHB) Levels in Healthy Subjects of Taiwan

洪苡昕 , Masters　　Advisor：林克亮　　

繁體中文 DOI： 10.6834/CSMU.2013.00103

γ-羥基丁酸（GHB）；氣相層析譜質譜儀（GC-MS）；偵測極限(LOD) ；定量極限(LOQ) ；線性；參考值；閾值； Gamma-hydroxybutyrate（GHB）； Gas chromatography-mass spectrometry（GC-MS）； Limits of detection（LOD）； Limits of quantitation （LOQ）； Linearrity ； Reference value ； Cut off value

Abstract │ Reference (181) │ Altmetrics

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Gamma-hydroxybutyrate （ GHB ） , an endogenous production substance in
mammalian brain, is one of three common date rape pills. Laboratory detection of GHB
in urine is important for clinical and forensic applications. We have developed
N-Methyl-N (trimethylsily) trifluoroacetamide （MSTFA）chemical derivatization
follow by gas chromatography-mass spectrometry （GC-MS） method for the detection
of low levels of GHB in urine and salivary and have used this method to establish a
reference range for normal population in Taiwan. The in house method was validated
for the analysis of GHB and was used to analyze urine samples and salivary fluid
collected from 60 and 60 healthy subjects, respectively. The limits of detection （LOD）
and quantitation（LOQ）obtained via this approach were 0.05 and 0.2 μg/mL,
respectively. The calibration curve exhibited linearity for all analyses with an upper
limit of linearity of 10000 ng/mL. The mean concentration of GHB was 1.65 μg/mL
（0.07∼6.21 μg/mL）in urine and 0.2 μg/mL（0.05∼1.75 μg/mL）in salivary fluid.
These data that led us to suggest cut off value for GHB is 10 μg/mL in urine and 4
μg/mL in salivary fluid.

Reference ( 181 ) 〈TOP〉

行政院衛生署97 年7 月藥物食品安全週報第146 期，2008。
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evidence in favour of a substitution mechanism. Alcohol Alcoholism.
連結：
Alexander Saytzeff. Ueber die Reduction des Succinylchlorids. Liebigs
連結：

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