雙模式 PET/SPECT雙同位素同步造影之散射修正

李易桓

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雙模式 PET/SPECT雙同位素同步造影之散射修正

Down-scatter Correction for Simultaneous Dual Isotopes PET/SPECT Imaging with sharing Detector

李易桓 , Masters　　Advisor：莊克士;林信宏　　

英文

雙同位素掃描；散射修正；正子斷層掃描；單光子斷層掃描； Dual isotope scan ； Scatter correction ； PET ； SPECT ； Sharing Detector ； slit-slat collimator ； pinhole

Abstract │ Reference (34) │ Altmetrics

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The capability of SPECT imaging developed on an preclinical PET scanner can provide a combined PET/SPECT dual modality imaging environment, potentially opening the opportunity for many new clinical and preclinical applications, However, an obstacle to the implementation of the protocol is the interference of signal between two isotope, particularly in the down-scatter from high energy gamma-ray into low energy window. In this work, we developed a new down-scatter correction method for simultaneous dual isotopes PET/SPECT imaging. A Siemens Inveon preclinical PET with a slit-slat collimator insert was modeled using the GATE/MPHG Monte Carlo simulation software developed by our laboratory. For dual imaging capability, dual energy window settings at 120-160 keV and 350-650keV were used to acquired SPECT and PET imaging, respectively. The procedure of the proposed method includes two steps: (1) A 18F uniform phantom needs to be acquired for establishing a transform function and a scaling factor between the two energy windows beforehand. (2) During dual isotopes simultaneous acquisition (DISA), the down-scatter distribution can be estimated by multiplying the acquired projections at 350-650keV with the transform function, and then the absolute scatter amount can be finally obtained by scaling the resulting scatter distribution using the scaling factor. Various phantoms were conducted to compare the image quality using the proposed method and triple energy window method, which is common used for scatter correction in DISA. The results indicated that image generated by our method is close to pure 99mTc isotope imaging, and the proposed method always outperforms the conventional triple energy window (TEW) method in terms of coefficient of variation (15.08% vs. 21.04%) and contrast recovery coefficient (0.848 vs. 0.58). In conclusion, we have developed a novel down-scatter correction method for DISA imaging. It is expected that the method can also be applied to dual isotopes SPECT imaging with high energy peaks that down-scattered to low photopeak data, such as Tc-99m/Tl-201

Reference ( 34 ) 〈TOP〉

Andreyev A and Celler A 2011 Dual-isotope PET using positron-gamma emitters Physics in medicine and biology 56 4539
連結：
Axelsson B, Msaki P and Israelsson A 1984 Subtraction of Compton-scattered photons in single-photon emission computerized tomography Journal of nuclear medicine: official publication, Society of Nuclear Medicine 25 490-4
連結：
Baum K G and Helguera M 2007 Execution of the SimSET Monte Carlo PET/SPECT simulator in the condor distributed computing environment Journal of digital imaging 20 72-82
連結：
Berman D S, Kiat H, Friedman J D, Wang F P, Van Train K, Matzer L, Maddahi J and Germano G 1993 Separate acquisition rest thallium-201/stress technetium-99m sestamibi dual-isotope myocardial perfusion single-photon emission computed tomography: a clinical validation study Journal of the American College of Cardiology 22 1455-64
連結：
Blumenthal G R and Gould R J 1970 Bremsstrahlung, synchrotron radiation, and Compton scattering of high-energy electrons traversing dilute gases Reviews of Modern Physics 42 237
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