二氧化鈦奈米顆粒對發育中斑馬魚之行為研究

林純瑤

doi:10.6346/NPUST.2010.00157

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二氧化鈦奈米顆粒對發育中斑馬魚之行為研究

Behavioral effects of titanium dioxide nanoparticles on larval zebrafish (Danio rerio)

林純瑤 , Masters　　Advisor：陳德豪;曾美珍　　

繁體中文 DOI： 10.6346/NPUST.2010.00157

奈米顆粒二氧化鈦；斑馬魚；行為；啶橘染色；氧化緊迫； titanium dioxide nanoparticles (TiO2 NP) ； zebrafish ； behavior ； acridine orange (AO) ； oxidative stress

Abstract │ Reference (82) │ Altmetrics

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Titanium dioxide nanoparticles (TiO2 NP) is a novel material that can be used in healthcare, cosmetics and environmental products. However, TiO2 NP would eventually flow into aquatic environment. Increased surface area of nanoparticles can potentially cause damage to aquatic lives. Behavior of fish provides connections to fish biochemistry and physiology processes, and can be a valuable tool to detect the influence of the environmental pressure on fishes. In addition, observing fish behaviors allow us to have a perspective on the influence of pollutants at the population level. In this study, fertilized zebrafish eggs were exposed to TiO2 NP (control, 0.1, 1.5, 1, 5 and 10 mg/l), and the hatching rate, mortality, malformation rate were observed every 12 hours. In addition, larval swimming ability was evaluated at 120 hours post fertilization. The result showed no significant difference in hatchability, survival, and malformation rate between groups, but TiO2 NP at 0.1, 0.5, 1 mg/l caused decreased average velocity and activity level of larval zebrafish. Co-exposure to either the glutathione precursor, N-acetylcysteine (NAC), or the glutathione synthesis inhibitor, buthionine sulfoximine (BSO), did not significantly alter the behavioral effects resulting from TiO2 NPs. Acridine orange staining of larvae showed no significant difference in apoptosis level between groups. Our data suggests that other factor(s) besides oxidative stress may contribute to the behavioral toxicity of TiO2 NPs. Our study also showed that the behavioral endpoints were more sensitive than the others (e.g., hatchability and survival) to detect toxicity of TiO2 NPs on developing fish.

Reference ( 82 ) 〈TOP〉

Atchison, G.J., Henry, M.G., Sandheinrich, M.B., 1987. Effects of metals on fish behavior: a review. Environmental Biology of Fishes 18, 11-25.
連結：
Barakat, M.A., 2005. Adsorption behavior of copper and cyanide ions at TiO2-solution interface. Journal of Colloid and Interface Science 291, 345-352.
連結：
Beauvais, S.L., Jones, S.B., Brewer, S.K., Little, E.E., 2000. Physiological measures of neurotoxicity of diazinon and malathion to larval rainbow trout (Oncorhynchus mykiss) and their correlation with behavioral measures. Environmental Toxicology and Chemistry 19, 1875-1880.
連結：
Bjerselius, R., Lundstedt-Enkel, K., Olse´n, H., Mayer, I., Dimberg, K., 2001. Male goldfish reproductive behavior and physiology are severely affected by exogenous exposure to 17-estradiol. Aquatic Toxicology 53, 139-152.
連結：
Brewer, S.K., Little, E.E., DeLonay, A.J., Beauvais, S.L., Jones, S.B., Ellersieck, M.R., 2001. Behavioral Dysfunctions Correlate to Altered Physiology in Rainbow Trout (Oncorynchus mykiss) Exposed to Cholinesterase-Inhibiting Chemicals. Archives of Environmental Contamination and Toxicology 40, 70-76.
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