口腔癌病患治療後之復發轉移與存活之探討-以中部某醫學中心為例

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口腔癌病患治療後之復發轉移與存活之探討-以中部某醫學中心為例

Exploring the Recurrence Metastasis and Survival after Treatment in Oral Cancer Patients : For Example of a Medical Center in Central Taiwan

林知瑩 , Masters　　Advisor：陳淑賢　　

繁體中文

口腔癌；復發；轉移；存活分析； Metastasis ； Survival analysis ； Oral cancer ； Recurrence

Abstract │ Reference (71) │ Altmetrics

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Purpose: This study aims to explore the recurrence metastasis and survival after treatment in oral cancer patients of a Medical center in central Taiwan. Analysis of prognosis and survival differences. In addition, for patients with different treatment effectiveness analysis and further improve the quality of oral cancer clinics improved. 
Methods: Object of study was obtained from april 2000 to August 2010 of medical center in the central Taiwan. Use of ICD-10 of International Classification of Diseases code, extract have clinical records and pathological biopsy of oral cancer patients, there were 898 patients chosen for the final analyses. Study chart records were retrospectively reviewed, include sociodemographic, personal habits, personal disease, cancer-related symptoms and patient status after treatment. Statistical methods used Descriptive statistics of population distribution and the percentage, Chi-square test analysis of the correlation in patient of recurrence metastasis and survival status, One-way ANOVA analysis of the differences in patient impact of recurrence metastasis and survival status, Kaplan-Meier survival analysis and Log-Rank test depict the survival curve and estimate the five-year survival rate and the relationship between survival of oral cancer patients.
Results: In this study, 898 patients were male (N=842,93.8%) and 56 were female (6.2%); the male-to-female ratio was 15.13: 1. The mean age at diagnosis was 51.95 year old. Most of the 60.1% patients had smoking, drinking and betel nut chewing habits; Buccal mucosa (33.1%) and tongue (27.8%) were the most common locations of involvement. The most common stage was stage IV (41.6%)；The overall recurrence rate was 38.1%, metastasis rate was 11%; Treatment of the survival highest In the whole surgical. Using Kaplan-Meier survival Analysis, the overall 5-year survival rate was 46.8%. According to the Log-Rank Test, we found the most important factors that correlated to survival were：tumor stage, tumor size, degree of differentiation, lymph node dissection, lymph node metastasis number , treatment. 　　
Conclusion: This study retrospectively reviewed 898 oral cancer patients and found that treatment and lymph node dissection have a significant correlation with recurrence, metastasis and survival rate. Although surgery is the gold standard for oral cancer treatment, further investigation with a prospective cohort study is needed to further clarify the relationship between physical and psychological factors and the survival of oral cancer patients.

Reference ( 71 ) 〈TOP〉

王宏銘、廖俊達、范網行、吳樹鏗、詹勝傑、閣紫宸（2009）。頭頸部鱗狀細胞癌治療的新進展。腫瘤護理雜誌，9（S）：342-346。
連結：
石壁瑜（2010）。口腔癌術後存活分析與其影響因素之探討。亞洲大學健康產業管理學系研究所碩士論文，台中市。
連結：
江季亭、林恕德、蘇哲俊、蔡國陽、連怡斌、黃耀輝與張尊國（2009）。土壤重金屬鎳含量與口腔癌發生率之空間相關性探討。農業工程學報，55（4）：19 -34。
連結：
行政院衛生署（2011）。中華民國一百年死因統計結果。取自衛生署統計室。
連結：
行政院衛生署（2010）。中華民國九十六年台灣癌症登記年報。取自國民健康局，台北，1-24。
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