Channel entry theory of formula recipes was a rarely discussed hypothesis in the development history of prescription formulology. Cross following herbs channel entry and development history of prescription formulology, it was to find the origin and process of development for concept of formula recipes channel entry in history. It only appeared the medical writers of Liu-Cun in early Mm dynasty and Wang-Ang in early Qing dynasty. Results showed that the theory of formula recipes channel entry started from Liu's and evolved from herbs channel entry hypothesis. And two hundred years later, the content of formula recipes channel entry was broadened and became the character istic of Yi-fang-ji-jie written by Wang's. Untill now, there is no strong evidence in historical materials demonstrating that both Liu's and Wang's had scholarly background in traditional Chinese medicine. From a broader extent, they might have accepted the concept of herbs channel entry theory from Yuan-su Zhang, Dong-yuan Lee and Hao-gu Wang in Jin-Yuan dynasty.