The ”Enrichment Program for Cultivating Problem Solving Abilities and Multiple Intelligences for Gifted Preschoolers”, supported by National Science Council, was established between 2003 and 2006 by National Taiwan Normal University in order to develop young gifted children with multiple intelligences, their problem solving abilities and creativity. Subjects were gifted preschoolers aged 4 to 5 years, including 41 gifted preschoolers and 10 twice exceptional children. This paper examines twice exceptional children's performance in inclusive settings and the talent development of six twice exceptional children after entering elementary schools. The excellent performance and progress of children verified this program worked very well, including the implementation of inclusive education. Individual talent development of gifted children with disabilities deserves educators' attention in order to best practice inclusion in gifted education.