運動誘發鳶尾素對肥胖合併間歇性低氧引起心肌纖維化的影響

Tsung-I Chen; Guan-Jie Wang

doi:10.5297/ser.1903.006

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P272 - 287

Social Sciences > Physical Education

DOI： 10.5297/ser

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運動誘發鳶尾素對肥胖合併間歇性低氧引起心肌纖維化的影響

Effects of Exercise-Induced Irisin on Cardiac Fibrosis Resulted from the Combination of Obesity and Intermittent Hypoxia in Rats

陳聰毅(Tsung-I Chen) ；王冠捷(Guan-Jie Wang)

大專體育學刊； 19卷3期 (2017 / 09 / 30) ， P272 - 287

繁體中文;英文 DOI： 10.5297/ser.1903.006

睡眠呼吸中止症；高脂飲食；骨骼肌； sleep apnea ； high fat diet ； skeletal muscle

Abstract │ Reference (42) │ Altmetrics

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The purpose of this study was to investigate whether irisin plays a key role in exercise-mediated effects on cardiac fibrosis in obese rats with obstructive sleep apnea (OSA). We used high-fat diet to develop obese animal model, which displays the intermittent hypoxia seen in OSA. Eight-week old male Sprague-Dawley rats were randomly assigned into control (CON), intermittent hypoxia (IH), exercise (EXE) and IH-induced in EXE (IHEXE) groups. Each group again divided into two subgroups, namely normal diet (ND) and high-fat diet (HFD) groups. The exercise and hypoxia protocols were explained as follows; exercise protocol: rats were trained on an animal treadmill for 12 weeks. IH exposure: at the week 11 and 12, rats were exposed to IH (8 hours/day) for 14 days. After the last treatment, rats were sacrificed, and the weights of epididymal fat, perirenal fat, soleus and gastrocnemius muscle were recorded. The myocardial levels of fibrosis index, concentrations of tumor necrosis factor-α (TNF-α) and interleukin-6 (IL-6), and irisin expression in skeletal muscle were determined. The findings in this study showed that compared to ND, HFD feeding increased the weight of epididymal and perirenal fat in CON, IH, EXE and IHEXE groups. Compared to CON+ND group, rats in CON+HFD and IH+ND group showed significantly higher levels of cardiac fibrosis index, myocardial TNF-α and IL-6 concentrations (p ＜ .05). We found lower weights of epididymal and perirenal fat, lower levels of cardiac fibrosis index, myocardial TNF-α and IL-6 in EXE and IHEXE rats compared to IH rats with ND and HFD. Moreover, higher soleus muscle to body weight ratio, gastrocnemius muscle to body weight ratio and upregulated irisin expression in skeletal muscle were found in EXE and IHEXE groups compared to IH group. In conclusion, 12-week exercise training can provide potent anti-fibrotic effects by attenuating the HFD- and IH-induced cardiac fibrosis in rats that is possibly through enhanced irisin expression in skeletal muscle.

Reference ( 42 ) 〈TOP〉

Chen, M. Y.-C.,Yang, K.-T.,Shen, Y.-J.,Cheng, C.-F.,Tu, W.-C.,Chen, T.-I.(2015).Role of sodium-hydrogen exchanger-1 (NHE-1) in the effect of exercise on intermittent hypoxia-induced left ventricular dysfunction.Chinese Journal of Physiology,58(4),254-262.
連結：
Chen, M. Y.-C.,Yang, K.-T.,Shen, Y.-J.,Cheng, C.-F.,Tu, W.-C.,Chen, T.-I.(2015).Role of sodium-hydrogen exchanger-1 (NHE-1) in the effect of exercise on intermittent hypoxia-induced left ventricular dysfunction.Chinese Journal of Physiology,58(4),254-262.
連結：
Lin, Y.-M.,Huang, S.-K.,Wang, H.-F.,Chen, L.-M.,Tsai, F.-J.,Hsu, H.-H.,Lee, S. D.(2008).Short-term versus long-term intermittent hypobaric hypoxia on cardiac fibrosis and Fas death receptor dependent apoptotic pathway in rat hearts.Chinese Journal of Physiology,51(5),308-316.
連結：
林瑞興(2006)。運動訓練介入對左心室構造功能之影響。大專體育學刊，8(3)，149-159。
連結：
黃森芳、陳聰毅(2015)。運動對肥胖合併阻塞型睡眠呼吸中止症引發心臟功能損傷之影響：肌肉激素的角色。大專體育，135，67-77。
連結：

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