To date we still lack an effective and safe treatment for the drooling that frequently occurs in children with cerebral palsy. In an effort to improve upon this condition, we evaluated the effectiveness of injecting botulinum toxin type A into the salivary glands in 5 children with cerebral palsy above the age of 4 years old. The frequency score and total score of drooling had decreased significantly by the second week after injection, and the severity score of drooling had decreased significantly by the fourth week. At the end of the eighth week, the effect of botulinum toxin type A had not subsided and the drooling frequency and severity had not returned to the original level. No complications were found. The injection of botulinum toxin type A into the salivary glands is a safe and effective treatment for sialorrhea in children with cerebral palsy.