Effects of Saponin from Solanum anguivi Lam Fruit on Heart and Kidney Superoxide Dismutase, Catalase and Malondialdehyde in Rat

O. O. Elekofehinti ； I.G. Adanlawo ； A. Fakoya ； J.A. Saliu ； S.A. Sodehinde

《Current Research Journal of Biological Sciences》 4卷4期 (2012/07) Pp. 530-533

並列摘要

Reactive Oxygen Species (ROS) are generated via normal metabolic processes or as the products of exogenous insults. They are capable of damaging essential biomolecules and accelerating cancer, cardiovascular diseases and neurodegenerative diseases. In this study, the effect saponin from Solanum anguivi (SAS) fruits on Superoxide Dismutase (SOD), catalase (CAT) and Lipid Peroxidation (LPO) in the homogenates of the hearts and kidney was evaluated. Thirty six male Wister rats of average weight125±12 g were divided into six groups of six animals each. Five treated groups received a daily dose of saponin at 20, 40, 60, 80 and 100 mg/kg respectively, while distilled water was administered to the control group for 3 weeks. Solanum anguivi saponin significantly increased (p＜0.05) both catalase and SOD activities in the heart, There was also corresponding increase in activities of both enzymes in the kidney but was not significant. MDA concentration was reduced significantly (p＜0.05) in both tissues. SAS exhibit both antioxidant and antiperoxidative properties.Saponin from Solanum anguivi could therefore be employed as sources of natural antioxidant boosters and for the treatment of some oxidative stress disorders in which free radicals are implicated.

並列關鍵字

Antioxidant ； antiperoxidative ； heart ； kidney ； oxidative stress