在監男性成年藥物濫用者之抑制控制神經機制：腦波研究

The neural mechanisms of inhibitory control in male adult offenders with drug abuse: an EEG investigation

陳巧雲(Chiao-Yun Chen) ； 游家權(Chia-Chuan Yu)

《藥物濫用防治》 3卷3期 (2018/09) Pp. 33-61

https://doi.org/10.6645/JSAR.201806_3(3).2

摘要

本研究以在監停止施用藥物之男性藥物濫用者為對象，欲瞭解在監停用毒品後其抑制控制歷程與一般對照之差異。行為結果顯示二組受試者在go正確率、go反應時間（與衝動性有關）、stop錯誤率及停止訊號反應時間（與抑制歷程有關）上，均無顯著差異。在腦波結果上發現，實驗組在失敗時的N2振幅（抑制歷程的早期電生理指標）顯著大於成功時的N2振幅。在抑制失敗的情境下，實驗組的N2振幅顯著大於控制組的N2。控制組在成功及失敗抑制情況下，N2振幅均無差異。實驗組的P3振幅（抑制歷程的晚期電生理指標）在成功情境下大於失敗情境，控制組則在二種情境下無顯著差異。這說明實驗組要成功的去進行抑制反應，可能資源需求更高，才能達到與一般人一樣的表現。N2振幅訊號可能源自前扣帶迴，藥物濫用可能與前扣帶迴的失能有關，該處的失能會導致抑制控制上的缺陷，造成無法充分抑制與物質使用有關的行為，例如戒掉濫用物質。

關鍵字

藥物濫用 ； 抑制控制 ； N2 ； P3

並列摘要

This study investigated male drug abusers who have stopped taking drugs, aiming to better understand any inhibitory control differences between the male offenders with drug abuse accepting the prison treatment and controls. Using a stop signal task, behavioral results showed that there was no significant difference between the two groups in go correct rate or go reaction time (related to impulsivity), or stop error rate and stop signal reaction time (related to inhibitory control). It was found that the N2 amplitude, relating to early inhibitory control, of the experimental group on failed inhibitory trials was significantly larger than that when they successfully stopped. Compared with control group, the N2 amplitude of the experimental group was significantly greater than that of the control group for failed trials. For the control group, no difference was found in N2 amplitude between trials where they failed or successfully inhibited responding on stop trials. The P3 amplitude, relating to later inhibitory control, was greater in successful inhibitory trials than in failed inhibitory trials in the experimental group, while the control group had no significant difference in the two conditions. This might indicate that the experimental group needed higher resources to achieve the same performance as the control group. The N2 signal may be derived from the anterior cingulate cortex (ACC) and drug abuse behavior may be associated with dysfunction of ACC, and this may lead to inhibitory control deficiencies, resulting in inability to adequately inhibit behavior associated with substance use, such as cessation of drug use.

並列關鍵字

drug abuse ； inhibitory control ； N2 ； P3