1991-1994年金門縣30歲以上成人高尿酸血症盛行率與危險因子研究

The Prevalence and Risk Factors of Hyperuricemia in a Community-Based Study Among Kinmen Island Adults ≥30 Years Old in 1991-1994

陳水湖(Shui-Hu Chen) ； 莊紹源(Shao-Yuan Chuang) ； 周碧瑟(Pesus Chou)

《台灣公共衛生雜誌》 24卷1期 (2005/02) Pp. 73-83

https://doi.org/10.6288/TJPH2005-24-01-07

摘要

目標：探討金門縣社區性高尿酸血症盛行率及其相關危險因子。方法：於1991到1994年間，共11,922之30歲以上居民完成所有研究步驟。由熟練之訪員—陽明十字軍，進行結構式問卷調查，並由公共衛生護士採集禁食血液進行生化檢驗。以邏輯斯複迴歸模式分析高尿酸血症之相關危險因子。結果：篩檢率為59.3%(1l,922/20,112)。高尿酸血症盛行率平均為25.4%，其中男性（尿酸值≥7.0mg/dl）為31.0%，女性（尿酸值≥6.0mg/dl）為20.9%。男性尿酸平均值為6.3±l.4mg/dl, 女性為5.0±1.4mg/dl，男性高於女性。以性別和年齡分層探討相關危險因數，男女兩性30~39歲者之相關危險因子為高肌酸酐、高血脂、肥胖、高血壓，與女性停經。40歲以上者，除了上述相關危險因子之外，喝酒與使用利尿劑也是其極重要的危險因子。結論：高尿酸血症的相關危險因子會隨著性別與年齡而改變。利尿劑使用的重要性隨著年齡而上升。飲酒、停經與否、分別為男、女性的重要危險因子。

關鍵字

高尿酸血症 ； 盛行率 ； 危險因子 ； 金門研究

並列摘要

Objectives: The purpose of present study was to investigate the prevalence and risk factors of hyperuricemia in Kinmen Island. Methods: A total of 11,922 residents aged ≥30 years completed all examinations of the survey in Kinmen Island between 1991 and 1994. The response rate was 59.3% (11,922/20,112). The physical examination and structured questionnaire were carried out by the Yang-Ming Crusade, a group of well-trained medical students. Overnight fasting blood was collected by public health nurses. The risk factors of hyperuricemia were determined using multivariate logistic regression. Results: The crude prevalence of hyperuricemia, defined as serum uric acid ≥7.0mgIdl for men and ≥6.0mg/dl for women, was 25.4% (3 1.0% for men, 20.9% for women). The means and standard deviation of uric acid were 6.3±1.5mg/dl for men and 5.0±1.4mg/dl for women. Men had higher uric acid levels than women (p＜0.05). According to the age and sex spectrum, the risk factors of hyperuricemia were hyperlipidemia, high creatinine, obesity, and hypertension among young men and women, aged 30-39 years old and menopausal for women. Middle and old aged group (40-59 yrs and ≥60 yrs) had the same risk factors as young aged group except alcohol consumption of man and the use of diuretics in both sexes. Conclusions: The risk factors of hyperuricemia were changed by sex and age. Use of diuretics became more important for middle-aged and elderly subjects. Alcohol consumption for men and menopausal for women were the most important risk factors of hyperuricemia.

並列關鍵字

hyperuricemia ； prevalence rate ； risk factor ； Kinmen study

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