老年族群使用抗膽鹼藥物對於認知功能的影響

吳怡慧 ； 王培寧

《臨床醫學月刊》 81卷1期 (2018/01) Pp. 10-16

https://doi.org/10.6666/ClinMed.201801_81(1).0002

摘要

老年族群因為罹患多種慢性疾病，往往成為不適當用藥的高風險群，又因為老化的生理變化，造成老年人對藥物的敏感性提升，出現不良反應的頻率與嚴重度都比青壯年族群要高。在各種不適當用藥與不良預後中，以抗膽鹼藥物對於老年族群的認知影響最常引起討論，本文將藉由文獻回顧，詳細介紹抗膽鹼藥物如何從微觀到巨觀等層面影響老年人的認知表現，同時彙整目前臨床常使用的藥物抗膽鹼效果評估方式，並針對非抗精神藥物的抗膽鹼藥物在認知功能的影響進行深入探討。

關鍵字

抗膽鹼藥物(anticholinergic drugs) ； 老化(aging) ； 認知(cognition) ； 失智(dementia)

參考文獻

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