Case Report: Histiocytic Sarcoma in A Mouse

病例報告：小鼠組織細胞肉瘤

梁鍾鼎(Chung-Tiang Liang) ； 劉振軒(Chen-Hsuan Liu) ； 黃彥智(Yen-Te Huang) ； 龐飛(Victor Fei Pang) ； 洪昭竹(Chou-Chu Hong) ； 陳憲全(Hans HC Chen)

《中華民國獸醫學會雜誌》 23卷6期 (1997/12) Pp. 506-514

https://doi.org/10.7009/JTCSVS.199712.0506

摘要

壹頭8.5月齡，雄性DBA/2J無特定病原小鼠臨床上無症狀因例行健康監測經病理學檢驗證實為組織細胞肉瘤。肉眼主要病變有：肝臟腫大斑駁與散發灰白色斑狀小結，脾臟腫大，左側睪丸及副睪較正常腫大2至3倍。腫瘤細胞侵犯肝臟、睪丸、副睪、肺臟，腎臟漿膜層等器官甚著。腫瘤細胞程多形性，但以紡綞形為多，其細胞核很大且濃染。細胞彼此黏著而界限不明。腫瘤細胞質淡染或含中等量淡紅色泡沫狀空泡。多核細胞極少或罕見。依據本腫瘤之發生部位，形態學及組織免疫化學特徵診斷為組織細胞肉瘤。

關鍵字

小鼠 ； 組織細胞肉瘤

並列摘要

Histiocytic sarcoma was diagnosed in a 8.5-month-old SPF inbred DBA/2J mouse on routine heaIth monitoring. Grossly, the tumor was characterized by hepatomegaly with mottled greyish spots, splenomegaly and enlargement of the left testis and epididymis. The neoplastic cells marked by infiltrating the liver, left testis and epididymis, lung, the serosa of kidneys and jejunum. The neoplastie cells exhibited moderate pleomorphism and ranged from fusiform to ovoid in shape, with large nuclei. The cytoplasm was pale staining or composed of moderate amount of light eosinophilic foamy vacuoles. Multinucleated giant cells were rarely seen. The morphological features with immunohistochemical characteristics of the present case were in favor of the diagnosis of histiocytic sarcoma.

並列關鍵字

Mice ； Histiocytic Sarcoma