中華民國小兒科醫學會第145屆學術演講會 教育演講：兒童疾病的新境界—C型肝炎病毒之母子傳染

The 145th Scientific Meeting of the Chinese Taipei Pediatric Association Continuing Medical Education: Recent Advances of the Childhood Diseases-Mother-to-Infant Transmission of Hepatitis C Virus

張美惠(Mei-Hwei Chang)

《Acta Paediatrica Sinica》 37卷s_1期 (1996/04) Pp. 13-15

https://doi.org/10.7097/APS.199604.0013

摘要

Mother-to-infant transmission of hepatitis C virus (HCV) does occur in a lower efficiency way(0-15％,average in 4.7％)in infants of HCV viremic mothers than that of hepatitis B virus. It is very likely due to the lower viral level of mothers. Infants of mothers coinfected by HCV and human immunodeficiency virus (HIV), or with high HCV RNA titer (＞10^6 copies/ml) are at high risk of HCV infection by their mothers. Persistence of HCV infection with transient or persistent abnormal aminotransferase levels occurred in most(81％) HCV infected infants studied longitudimally, although normal liver function profile was also observed. Up to now, no effective way can prevent mother-to-infant transmission of HCV. Further investigation to understand more the natural history of infants perinatally infected by HCV and the indication for antiviral therapies are needed.

並列摘要

Mother-to-infant transmission of hepatitis C virus (HCV) does occur in a lower efficiency way(0-15％,average in 4.7％)in infants of HCV viremic mothers than that of hepatitis B virus. It is very likely due to the lower viral level of mothers. Infants of mothers coinfected by HCV and human immunodeficiency virus (HIV), or with high HCV RNA titer (＞10^6 copies/ml) are at high risk of HCV infection by their mothers. Persistence of HCV infection with transient or persistent abnormal aminotransferase levels occurred in most(81％) HCV infected infants studied longitudimally, although normal liver function profile was also observed. Up to now, no effective way can prevent mother-to-infant transmission of HCV. Further investigation to understand more the natural history of infants perinatally infected by HCV and the indication for antiviral therapies are needed.