Association of Adiponectin Gene-11377C>G Polymorphism with Adiponectin Levels and the Metabolic Syndrome in Thais

泰國人的脂聯素基因-11377C>G多型性與脂聯素濃度和代謝症候群之關聯性

Kanjana Suriyaprom ； Benjaluck Phonrat ； Rungsunn Tungtrongchitr

《Asia Pacific Journal of Clinical Nutrition》 23卷1期 (2014/03) Pp. 167-173

https://doi.org/10.6133/apjcn.2014.23.1.01

摘要

The metabolic syndrome is related to increased risk of developing cardiovascular disease and type 2 diabetes. Adiponectin is an adipocyte-secreted protein with insulin-sensitizing and anti-atherogenic properties. The aims of this study were to evaluate adiponectin levels and biochemical parameters in metabolic-syndrome subjects and healthy controls. The study also sought to identify links between two polymorphisms, -11377C＞G (rs266729) and +45T＞G (rs2241766) of the adiponectin gene, in relation to adiponectin levels and the metabolic syndrome. Three hundres and thirty-two Thai volunteers: 164 metabolic-syndrome subjects and 168 healthy control subjects were investigated. The adiponectin and HDL-C levels of the metabolic-syndrome group were significantly lower than the control group (p＜0.001). Decreased concentration of adiponectin was associated with -11377C＞G polymorphism (p＜0.001); this polymorphism was significantly more frequent in the metabolic syndrome group than in the control group (p＜0.001). However, +45T＞G polymorphism of the adiponectin gene was found not to be related to adiponectin level or metabolic syndrome. Therefore, -11377C＞G polymorphism was related to the metabolic syndrome susceptibility, and this polymorphism impacted on circulating adiponectin concentrations among Thais.

關鍵字

代謝症候群 ； 內臟型肥胖 ； 脂聯素 ； 基因多型性 ； 泰國人

並列摘要

The metabolic syndrome is related to increased risk of developing cardiovascular disease and type 2 diabetes. Adiponectin is an adipocyte-secreted protein with insulin-sensitizing and anti-atherogenic properties. The aims of this study were to evaluate adiponectin levels and biochemical parameters in metabolic-syndrome subjects and healthy controls. The study also sought to identify links between two polymorphisms, -11377C＞G (rs266729) and +45T＞G (rs2241766) of the adiponectin gene, in relation to adiponectin levels and the metabolic syndrome. Three hundres and thirty-two Thai volunteers: 164 metabolic-syndrome subjects and 168 healthy control subjects were investigated. The adiponectin and HDL-C levels of the metabolic-syndrome group were significantly lower than the control group (p＜0.001). Decreased concentration of adiponectin was associated with -11377C＞G polymorphism (p＜0.001); this polymorphism was significantly more frequent in the metabolic syndrome group than in the control group (p＜0.001). However, +45T＞G polymorphism of the adiponectin gene was found not to be related to adiponectin level or metabolic syndrome. Therefore, -11377C＞G polymorphism was related to the metabolic syndrome susceptibility, and this polymorphism impacted on circulating adiponectin concentrations among Thais.

並列關鍵字

metabolic syndrome ； visceral obesity ； adiponectin ； gene polymorphism ； Thais