Actinomycosis is a rare pulmonary infection that can mimic a variety of chronic suppurative lung diseases or lung tumors. Involvement of the vertebral column is very rare. In this article, we report the case of a 28-year-old man who presented with upper back pain for 6 months; radiological examinations showed right upper lung consolidation and multi-segmental spondylitis of the thoracic spine. Chronic inflammation was observed during ultrasonography-guided aspiration and conventional computed tomography-guided biopsy. Wedge resection via video-assisted thoracoscopic surgery of the right upper lung and histopathological examination of the tissue established a diagnosis of actinomycosis. The patient was treated with intravenous penicillin G for 14 days followed by oral amoxicillin/clavulanic acid for 3.5 months, without any sequelae. Actinomycosis infection is rare; therefore, a diagnosis can be difficult to attain. A high degree of clinical suspicion, an early diagnosis, and appropriate treatment may prevent morbidity considerably.