Cross border S&T collaboration has been one of the important elements of globalization. In recent decades, cross-border S&T collaboration is not limited in developed world but also has expanded to developing countries. Especially, since the 11th Five-Year Plan, China intends to engage international S&T cooperation more aggressively. In the post-ECFA period, we may expect the cross-strait relations to reach S&T dimension through the closer connection in industrial sectors. Finally, this article suggests strategies in managing the cross-strait cooperation on S&T by drawing on China's international cooperation experience with advanced countries.