台灣地區帕金森氏症之流行病學研究

The Epidemiologic study of Parkinson’s Disease in Taiwan

曾菁英(Ching-Ing Tseng)

指導教授 ： 楊俊毓

高雄醫學大學/醫學院/醫學研究所/碩士(2007年)

摘要

隨著醫療水準的提升，國民的平均餘命延長，使得台灣地區老年人口數不斷增加。帕金森氏症，為因年齡增加而發生的神經退化性疾病中排行第二，由於其所產生的運動障礙，對於個人生活品質的影響之甚，值得注意。本研究是以1996年至2004年，健保資料庫中的抽樣歸人檔為資料來源，ICD-9-CM碼為332及A-Code為A221認定為帕金森氏症患者，估算其盛行率、發生率，以回溯的方式，利用新發生的個案與未得病的民眾進行比較，進行危險因子的評估。
帕金森氏症在台灣地區的盛行率為每十萬人口有340人，經過8年的追蹤，有791人得病，發生率為每十萬人年有345.46人，兩者均會隨著年齡的增加而上升。帕金森氏症的盛行率從50-59歲的民眾為每十萬人口有130人上升至85歲以上的民眾為每十萬人口有726.67人。帕金森氏症的發生率從50-59歲的民眾為每十萬人年有131.03人上升至85歲以上的民眾為每十萬人年有979.31人。年齡的增加、罹患糖尿病、中風、精神疾病會增加得到帕金森氏症的風險；罹患高血脂症則會降低得到帕金森氏症的風險。台灣地區帕金森氏症的盛行率高於日本及中國所進行的調查，發生率則低於義大利、西班牙、荷蘭等西方國家，未來研究方向可針對原發性帕金森氏症進行研究。

關鍵字

帕金森氏症 ； 發生率 ； 盛行率 ； 健保資料庫

並列摘要

In Taiwan’s aging society, the proportion of the elderly with Parkinson’s disease (PD) is rising and this brings about some effects on the quality of our daily life. We used Panel Claims Data of National Health Insurance Beneficiaries from 1996 to 2004 to calculate the level of PD in Taiwan. A person was considered as PD if the database claim contained the ICD-9-CM diagnosis code 332.0, or A code A221. Then, prevalence and incidence rates were calculated and we conducted retrospective methods to analyze risk factors between people with and without PD.
The prevalence rate of Parkinson’s disease was 340 per 100,000 population in Taiwan. After a follow-up period of 8 years, 791 subjects with incident PD were identified. The prevalence and incidence of PD increased with age, with prevalence rates for PD increasing from 130 per 100,000 population in subjects 50 to 59 years of age, to 726.67 per 100,000 population for those aged 80 or older. Incidence rates for PD increased from 131.03 per 100,000 person-years in subjects 50 to 59 years of age, to 979.31 per 100,000 person-years for those 80 or older. Ageing, diabetes, stroke, and psychosis were significantly more frequent in PD than controls, but hyperlipidemia was significantly less frequent in PD than controls. The prevalence rate in Taiwan was higher than in Japan and China. The incidence rate in Taiwan was lower than in Italy, Spain, and the Netherlands. Further research could focus on the idiopathy of Parkinson’s disease.

並列關鍵字

Parkinson’s disease ； incidence rate ； prevalence rate ； NHIRD

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