頸部淋巴結大小及轉移對口腔癌患者存活率的影響

Influence of the Size and Metastasis of Cervical Lymph Nodes on the Survival of Oral Cancer Patients

陳金勝(Chin-Sheng Chen) ； 蔡國陽(Kuo-Yang Tsai) ； 洪敦杰(Duen-Jye Hong)

《中華牙醫學雜誌（中文版）》 1卷1期 (2005/03) Pp. 25-31

https://doi.org/10.7106/CJD.200503.0025

摘要

醫學界大多認為頸部林巴結腫大和組織學上的轉移，對口腔癌的治療及預後的評估是重要的因素。本研究對象為127位實施頭部淋巴結廓清手術並有術前電腦斷層檢查的口腔癌患者。經分析其頸部淋巴結大小及淋巴結轉移和5年存活率的相關性，發現84位頸部淋巴結無組織學上轉移之患者，其5年存活率為60.7%，43位有組織學上轉移之患者其5年存活率只有23.3% (p=0.000)。患者頸部淋巴結大小和組織學上之淋巴結轉移，也有明顯相關(p=0.000)。然而，先將有無組織學上淋巴結轉移之患者區分開後，84位無淋巴結轉移之患者，頸部淋巴結大小和口腔癌患者之5年存活率無明顯相關(p=0.81)；43位有淋巴結轉移之患者，頸部淋巴結大小和口腔癌患者之5年存活率也無明顯相關(p=0.96)。我們的結論是患者頸部淋巴結有無組織學上轉移，是決定腔癌患者5年存活率之重要因子。

關鍵字

口腔癌 ； 淋巴結 ； 頸部轉移 ； 存活率

並列摘要

It is well accepted that the size and the presence of pathological metastasis of cervical lymph nodes are important factors in the treatment and prognosis of oral cancer patients. The study subjects included 127 oral cancer patients who underwent preoperative computed tomography, accompanied by either radical neck dissection or supraomohyoid neck dissection. The purpose of this study was to evaluate the influence of the size and presence of metastasis of cervical lymph nodes on oral cancer patients' 5-year survival rate. We found that the 5-year survival rate was 60.7% in the group of 84 patients without cervical lymph node metastasis. In contrast, the 5-year survival rate was 23.3% in the group of 43 patients with histologically proven cervical lymph node metastasis (p=0.000). There was a significant association of the size of the cervical lymph node with histologically proven cervical lymph node metastasis (p=0.000). However, after the patients were divided in 2 groups based on the presence or absence of pathological metastasis of the cervical lymph node, we found that in the group of 84 patients without cervical lymph node metastasis, the size of cervical lymph nodes was not significantly correlated with the oral cancer patients' 5-year survival rate (p=0.81). Likewise in the other group of 43 patients with cervical lymph node metastasis, it was found that the size of cervical lymph nodes was also not significantly correlated with the oral cancer patients' 5-year survival rate (p=0.96). We conclude that the presence of histologically proven cervical lymph node metastasis is an important factor for determining the 5-year survival rate of oral cancer patients.

並列關鍵字

oral cancer ； lymph node ； pathological metastasis ； survival