木耳萃取物抑制蝕骨細胞活性

Inhibition on Osteoclasts Activity of Auricularia polytricha Extracts

楊淑惠(Shu-Hui Yang) ； 楊惠婷(Hui-Ting Yang) ； 劉虹君(Hung-Chun Liu)

《台灣農業研究》 66卷3期 (2017/09) Pp. 261-265

https://doi.org/10.6156/JTAR/2017.06603.09

摘要

本試驗以大鼠卵巢切除(OVX)模式，探討餵食木耳子實體(AP)或木耳萃取物(APE)對骨質代謝的影響及其機制。SD雌鼠分成3組，偽手術正常飼料組(V0)，卵巢切除給予木耳子實體粉末組(A1)，或卵巢切除給予木耳萃取物組(A2)。研究結果顯示，餵食木耳子實體粉末可以有效改善OVX大鼠的血脂肪值，但對改善骨質代謝效果不顯著。餵食木耳萃取物大鼠的血液生化值及其骨質密度可以改善至接近偽手術組，探討其機制發現餵食木耳萃取物顯著增加卵巢切除大鼠血漿中的蝕骨細胞抑制因子濃度及血鈣濃度。

關鍵字

木耳子實體 ； 木耳萃取物 ； 卵巢切除 ； 骨質密度 ； 骨源鹼性磷酸酶 ； 蝕骨細胞抑制因子

並列摘要

This study investigated the effect of bone metabolism and mechanism of feeding Auricularia polytricha fruiting body powder (AP) or extract (APE) on ovariectomized (OVX) rats. Female Sprague Dawley rats were divided into 3 groups, sham operated group fed on chow diet (V0), OVX fed on AP (A1) group or OVX fed on APE (A2) group. AP treatment effectively improved blood lipid values, but not significantly affected the bone metabolism. The blood biochemistry values and bone density of APE treatment can be improved to near sham operated group. APE treatment significantly increased osteoprotegerin concentration and calcium concentration of plasma on ovariectomized rats.

並列關鍵字

Auricularia polytricha powder ； Auricularia polytricha extracts ； Ovariectomy ； Bone density ； Bone-specific alkaline phosphatase ； Osteoprotegerin