Resveratrol Enhances Therapeutic Effect on Pancreatic Regeneration in Diabetes Mellitus Rats Receiving Autologous Transplantation of Adipose-derived Stem Cells

Tung-Sheng Chen ； Pei-Fang Lai ； Chia-Hua Kuo ； Cecilia Hsuan Day ； Ray-Jade Chen ； Tsung-Jung Ho ； Yu-Lan Yeh ； B. Mahalakshmi ； Vijaya Padmaviswanadha ； Wei-Wen Kuo ； Chih-Yang Huang

《The Chinese Journal of Physiology》 63卷3期 (2020/06) Pp. 122-127

https://doi.org/10.4103/CJP.CJP_3_20

摘要

Pancreatic damage is the major causative agent in type 1 diabetes mellitus (DM). Several strategies have been suggested to regenerate pancreatic functions, such as stem cell transplantation and administration of active components isolating from natural herbals. This study aims to investigate if the synergistically protective effect on damaged pancreatic tissues can be observed in STZ-induced DM rats with autologous transplantation of adipose-derived stem cells (ADSC) coupling with oral administration of resveratrol. Pathological conditions can be recognized in DM rats with pancreatic damage, including reduction of islet size, suppression of survival markers, downregulation of AMPK/Sirt1 axis, and activation of apoptotic signaling. Autologous transplantation of ADSC slightly improves pancreatic functions, whereas autologous transplantation of ADSC coupling with oral administration of resveratrol significantly improves pancreatic functions in DM rats. We suggest that oral administration of resveratrol may enhance the therapeutic effect on DM patients receiving autologous transplantation of ADSC.

關鍵字

Diabetes ； mesenchymal stem cells ； pancreas ； resveratrol

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