口服中藥成藥對血清腎上腺皮質醇濃度的抑制效應

Suppressive Effect of Formulated Herb Drug on Serum Cortisol Level

陳育堂(Yu-Tang Chen) ； 王榮德(Jung-Der Wan) ； 張智仁(Chin-Jen Chang)

《中華民國公共衛生學會雜誌》 11卷2期 (1992/06) Pp. 131-139

https://doi.org/10.6288/JNPHARC1992-11-02-06

摘要

The objective of this study is to determinate the effect of formulated herb drugs on serum cortisol level. After eliminating most conditions (including taking various kinds of drugs) known to influence serum cortisol level, we have selected 59 subjects who ever used to taking formulated herb drugs at our clinic of family medicine. 76 subjects who never use herb drug were also recruited for comparison. Serum cortisol levels were measured ill 8 a.m. and 4 p.m. respectively by radioimmunoassay method. The results revealed that the serum cortisol values at S a.m. of the above two groups (control vs . user, mean±S.D.) were: 11.9±4.1μg/dL, 6.3±4.8μg/dL respectively, P＜0.0001; and those at 4 p.m. were 6.3±3.0μg/dL, 3.9±2.9μg/dL respectively, P＜0.000l. Because we have excluded all other alternative explanations, we conclude that taking formulated herb drugs may reduce the serum cortisol and probably result in adrenal insufficiency. The degree of suppression was greater among people who take formulated herb drugs for arthralgia or/and bone pain than those who take for other reasons. We recommend that history of taking formulated herb drugs should be routinely asked in our regular clinic, especially for patients with symptoms of bone pain and/or arthralgia. Thus, we can early detect adrenal insufficiency and prevent complication. The limitation of our study is that we have no determination of steroid content inside herb drugs, and hope that further research should be directed to resolve this problem.

關鍵字

中藥成藥 ； 腎上腺皮質醇

並列摘要

The objective of this study is to determinate the effect of formulated herb drugs on serum cortisol level. After eliminating most conditions (including taking various kinds of drugs) known to influence serum cortisol level, we have selected 59 subjects who ever used to taking formulated herb drugs at our clinic of family medicine. 76 subjects who never use herb drug were also recruited for comparison. Serum cortisol levels were measured ill 8 a.m. and 4 p.m. respectively by radioimmunoassay method. The results revealed that the serum cortisol values at S a.m. of the above two groups (control vs . user, mean±S.D.) were: 11.9±4.1μg/dL, 6.3±4.8μg/dL respectively, P＜0.0001; and those at 4 p.m. were 6.3±3.0μg/dL, 3.9±2.9μg/dL respectively, P＜0.000l. Because we have excluded all other alternative explanations, we conclude that taking formulated herb drugs may reduce the serum cortisol and probably result in adrenal insufficiency. The degree of suppression was greater among people who take formulated herb drugs for arthralgia or/and bone pain than those who take for other reasons. We recommend that history of taking formulated herb drugs should be routinely asked in our regular clinic, especially for patients with symptoms of bone pain and/or arthralgia. Thus, we can early detect adrenal insufficiency and prevent complication. The limitation of our study is that we have no determination of steroid content inside herb drugs, and hope that further research should be directed to resolve this problem.

並列關鍵字

formulated herb drug ； cortisol