目標:探討Statin劑量效應與罹患肝癌之相關性。方法:本篇研究為病例對照研究,利用國衛院2010年承保抽樣檔納入50歲以上2005-2010年糖尿病之群體(ICD-9 code: 250.x)至少使用OAD或insulin三個月以上之個案往前回溯Statin暴露量。病例組為糖尿病且被確診肝癌個案(ICD-9: 155),對照組為糖尿病並未診斷肝癌之個案。結果:HBV(累積劑量>298 DDDs:OR=0.41; 95% CI: 0.24-0.72)或HCV(累積劑量>205 DDDs: OR=0.25; 95% CI: 0.13-0.48)糖尿病患者若服用Statin累積劑量越高與降低肝癌之風險呈現劑量效應關係(p<0.001)。結論:HBV、HBC之糖尿病個案先前合併使用糖尿病藥物與Statin與降低肝癌之風險呈現劑量效應相關。
Objectives: To determine the relationship between the dose effect of Statin and the risk of HCC. Methods: This study was a case-control study. All participants were > 50 years of age and were diagnosed with diabetes (ICD-9: 250.x0, 205.x2) and were treated with an anti-diabetic agent for at least for 3 months according to the NHID, LHID 2010 (Longitudinal Health Insurance database 2010). We captured the use of a Statin before the index date in patients with type II diabetes. Patients diagnosed with a hepatoma (ICD-9:155) were defined as the case group. Results: The risk of hepatoma was reduced in patients with higher cumulative DDDs Statin use compared to Statin non-users (HBV population: cumulative dose> 298 DDDs [OR=0.41, 95% CI: 0.24-0.72]; HCV population: cumulative dose > 205 DDDs [OR= 0.25; 95% CI: 0.13-0.48]). Conclusions: A dose-response relationship exists between lower risk for hepatoma and higher cumulative DDDs of Statin use.