- 期刊
PROGNOSTIC FACTORS AND OUTCOMES OF POSTOPERATIVE RADIOTHERAPY FOR MALIGNANT GLIOMAS: A SINGLE-INSTITUTION EXPERIENCE
惡性腦瘤患者接受術後放射治療之分析及其治療結果
摘要
目的：評估惡性腦瘤病患術後接受放射治療的治療成果。材料與方法：回顧自西元2007年4月至2014年10月間，因為惡性腦瘤接受術後放射治療的病患。病人之臨床表現、手術切除狀態、影像特徵與整體存活（overall survival）都被檢視與分析。結果：共34位病人被納入本研究。其中13位病人（38%）被診斷為未分化性星狀細胞瘤，21位病人（62%）被診斷為多型性膠狀母細胞瘤。追蹤期的中位數為14個月（範圍從4到46個月）。全部病人整體存活的中位數為14.3個月（範圍從3.8到45.7個月）。未分化性星狀細胞瘤和多型性膠狀母細胞瘤之整體存活中位數分別為15.2和12.3個月（p= 0.0355）。在多型性膠狀母細胞 瘤的病人當中，第一組病患（腫瘤切除大於50%）之整體存活率較第二組病患（腫瘤切除小於50%）為高（p=0.0225）。結論：其他統計資料相比，我們的研究結果顯示：針對惡性腦瘤病患的治療我們有相似的整體存活率。而手術切除腫瘤的程度在多型性膠狀母細胞瘤的病患中占有重要的角色。
並列摘要
Purpose : To investigate the prognostic factors and treatment outcomes of patients with malignant gliomas treated with postoperative radiotherapy. Material and Methods : We retrospectively reviewed the medical records of patients with malignant gliomas who received postoperative radiotherapy in our department between April 2007 and October 2014. Clinical characteristics, surgical resection status, and image findings of these patients were reviewed and analyzed. The primary endpoint was overall survival (OS). Results : Thirty-four patients were included in the study. Thirteen patients (38%) were diagnosed with anaplastic astrocytoma (AA) and 21 patients (62%) with glioblastoma (GBM). The median follow-up time was 14 months (range: 4–46 months). The median OS for all patients was 14.3 months (range: 3.8–45.7 months). The median OS of patients with AA and those with GBM were 15.2 and 12.3 months, respectively (p = 0.0355). In patients with GBM, group 1 (tumor resected more than 50%) had better OS than group 2 (tumor resected less than 50%, p = 0.0225). Conclusions : Our results showed similar OS to published articles. Surgical resection status was demonstrated to be an important prognostic factor for OS in patients with GBM.
延伸閱讀
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