Carvedilol用於類固醇引起的酒渣鼻之案例報告

Carvedilol for the Treatment of Steroid- Induced Rosacea: Case Report

蘇玉惠(Yu-Hui Su) ； 郭震羣(Chen-Chun Kuo) ； 楊璦瑜(Ai-Yu Yang)

《臺灣臨床藥學雜誌》 24卷4期 (2016/12) Pp. 360-366

https://doi.org/10.6168/FJCP.2016.2404.12

摘要

Carvedilol 是非選擇性β-腎上腺素受體拮抗劑。它已被證明具有抗氧化和抗發炎，能夠有助於酒渣鼻的治療。局部類固醇首次在1951 年推出後，之後無控制地使用是常見的問題。在臉部經常過度使用局部類固醇可能會產生皮膚併發症，在酒渣鼻的臨床診斷上為「類固醇引起酒渣鼻」。如果不治療，可能引起永久性的皮膚萎縮及毛細血管擴張。將根據文獻回顧，探討類固醇引起酒渣鼻的非藥物、藥物治療。再藉由兩個案例報告，評估carvedilol 使用於類固醇引起酒渣鼻的有效性、安全性，以提供臨床醫療人員治療上的另一個選擇。

關鍵字

類固醇引起的酒渣鼻 ； carvedilol ； 反彈現象

並列摘要

Carvedilol is a nonselective β-adrenergic blocking agent. It has been shown to have antioxidant and anti-inflammatory actions, which may contribute to its efficacy in rosacea. Topical steroids were first introduced for use in 1951, then uncontrolled use has been a common problem. The excessive, regular use of topical steroids on the face maybe produces skin complications, clinically indistinguishable from rosacea -- steroid-induced rosacea. If left untreated, permanent skin atrophy and telangiectasia can induced. According to the literature review, we discussed the nonpharmacologic and pharmacologic interventions for steroid-induced rosacea. We evaluated the efficacy and safety of carvedilol by literature review, hope to provied clinical staff another choice for treatment.

並列關鍵字

Steroid Induced Rosacea ； Carvedilol ； Rebound Phenomenon