Bowel metastasis from lung cancer has rarely been described. In this study, we report on a 72-year-old man with squamous cell carcinoma of the lung and his status post-operation. He was noted to have tarry stool and decreased levels of hemoglobin. A colonoscopy was performed and a biopsy of a descending colon lesion showed metastatic squamous cell carcinoma. On F-18 fluoro-2-deoxy-D-glucose positron emission tomography/ computed tomography (F-18 FDG PET/CT) images, an intensely FDG-avid colon lesion was compatible with a metastatic lesion. In addition, several focally intense FDG-avid lesions were found in the small bowel with corresponding mass-like lesions on CT images. Metastasis to the small bowel was highly suspected.