F-18 FDG PET/CT Imaging of Anti-Synthetase Syndrome: A Case Report

案例報告：氟-18去氧葡萄糖正子斷層造影於抗合成酶抗體症候群的應用

陳迺傑(Nai-Chieh Chen) ； 張雁翔(Yen-Hsiang Chang)

《核子醫學暨分子影像雜誌》 33卷1期 (2020/03) Pp. 37-42

https://doi.org/10.6332/ANMMI.202003_33(1).0005

摘要

Anti-synthetase syndrome (ASS) is a rare autoimmune disease. The diagnosis of ASS often requires multidisciplinary approaches. We presented a 63-year-old female patient with progressively multiple joints pain for 3 months. The diagnosis of ASS was established based on the presence of antibodies against aminoacyl transfer RNA (tRNA) synthetases and clinical features (e.g. interstitial lung disease [ILD], myositis, arthritis, and mechanic's hand). F18-labeled fluoro-2-deoxyglucose (F18-FDG) and positron emission tomography/computed tomography (F18-FDG PET/CT) showed no significant malignancy-associated FDG uptake, but there was diffuse increased uptake in the bilateral lungs, skeleton muscles, and multiple joints. We suggest that F-18 FDG PET/CT may aid in the evaluation of ASS by assessing the extent of inflammation throughout the body.

關鍵字

autoimmune disease ； anti-synthetase syndrome ； F18-FDG PET/CT

並列摘要

抗合成酶抗體症候群（anti-synthetase syndrome）是一種罕見的自體免疫疾病。其診斷需要結合多項診斷方法來建立。我們探討的案例為一名63歲女性，主訴為關節疼痛，此症狀於3個月內快速惡化。因為檢測出抗合成酶抗體以及臨床表現（肺間質性病變、肌炎、關節炎、以及技工手）而診斷為抗合成酶抗體症候群。本案例接受了正子造影並未發現體內有潛在癌病變相關之異常攝取，但顯示出氟-18去氧葡萄糖的攝取值在兩側肺葉、肌肉、以及關節處有瀰漫性上升的情形。我們認為正子造影可用以偵測全身發炎的情形，在抗合成酶抗體症候群的評估上有重要幫助。

並列關鍵字

氟-18去氧葡萄糖 ； 正子斷層造影 ； 抗合成酶抗體症候群