Systems Biology has attracted increasing attention in recent years mainly because of the success in high-throughput technologies, which have generated a large amount of data. This relatively new field requires significant computational capability in addition to the integration of physics, chemistry, and biology. In this regard, chemical engineers appear to be well prepared to take on this challenge. However, new issues arising from specific biological characteristics impede the direct transfer of chemical engineering tools to this area. In addition to the traditional problems in thermodynamics, transport phenomena, and kinetics, biological systems are complicated by the highly networked biological molecules, and an even larger number of uncertain or unknown components. The analysis, design, and prediction in the presence of such complexity and uncertainty require new tools, which call for creativity and thorough understanding in biological chemical and physical systems.
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