Fibroblast growth factor-23 and phosphorus related factors in young Japanese women: a cross-sectional study

磷平衡是由饮食摄入量、肠道吸收和肾小管对磷的重吸收来确定的。血清成纤维细胞生长因子23（FGF-23）被认为是慢性肾脏病患者和健康人磷代谢紊乱的一个早期敏感生物标志物。然而，评估健康人FGF-23血清浓度的研究数量有限。本横断面研究的目的是：在182名日本年轻女性（平均年龄为19.5±0.4岁）中研究血清FGF-23与磷相关因子之间的关系。校正初潮年龄和体重之后，我们发现较高的血清无机磷浓度与较低的血清1,25-二羟基维生素D浓度和脂肪、较高的磷和钙摄入存在弱相关，但与较高的血清FGF-23显著相关。这些结果表明，在日本年轻女性中，FGF-23可能反映磷的营养状态。然而，值得注意的是包括初潮年龄和身体状况（如体重）等反映成熟的指标，可能与血清FGF-23浓度有关。

關鍵字

成纤维细胞生长因子23 ；磷；钙；骨密度；日本年轻女性

並列摘要

Phosphorus homeostasis is determined by dietary intake, intestinal absorption, and renal tubular reabsorption of phosphorus. Serum fibroblast growth factor-23 (FGF-23) is considered to be a sensitive early biomarker of disordered phosphorus metabolism in both patients with chronic kidney diseases and healthy subjects. However, the number of studies evaluating serum FGF-23 concentrations in healthy subjects is limited. The objective of this cross-sectional study was to examine the relationship between serum FGF-23 concentrations and phosphorus related factors in 182 young Japanese women (mean age, 19.5±0.4 years). We found that higher serum concentrations of inorganic phosphorus and lower serum concentrations of 1,25-dihydroxy vitamin D as well as lower fat but higher phosphorus and calcium intake were weakly but significantly associated with high serum concentrations of FGF-23, adjusted for postmenarcheal age and body weight. These results suggested that in young Japanese women, serum FGF-23 might be indicative of phosphorus nutrition status. However, it is worthy of note that maturity factors, including postmenarcheal age and physical attributes, such as body weight, might be related to serum FGF-23 concentrations.

並列關鍵字

fibroblast growth factor-23 ； phosphorus ； calcium ； bone mineral density ； young Japanese women

國際替代計量

Fibroblast growth factor-23 and phosphorus related factors in young Japanese women: a cross-sectional study

全文下載

主題瀏覽